WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H407500
CAS#: Unknown
Description: PZ-285 is a potent anticancer agent. Pz 285 has excellent potential as a chemotherapeutic anticancer agent. The in vivo activity of Pz 285 improves survival, inhibits primary tumor regrowth, and inhibits lung tumor metastasis compared to vehicle control animals; Pz 285 has similar antitumor activity to the clinically active agent Dox.
Hodoodo Cat#: H407500
Name: PZ-285
CAS#: Unknown
Chemical Formula: C42H50N8O14
Exact Mass: 890.34
Molecular Weight: 890.904
Elemental Analysis: C, 56.62; H, 5.66; N, 12.58; O, 25.14
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Synonym: PZ-285; PZ 285; PZ285; Pz-285; Pz 285; Pz285; Porphyrazine Diol; H2Pz(A3B)
IUPAC/Chemical Name: N/A
InChi Key: PURPDMVLMICIQP-GIEDQAFWSA-N
InChi Code: InChI=1S/C42H50N8O14/c1-37(53-7)39(3,55-9)61-25-23(59-37)31-44-29-21-19(15-17-51)13-14-20(16-18-52)22(21)30(43-29)45-32-24-26(62-40(4,56-10)38(2,54-8)60-24)34(47-32)49-36-28-27(35(50-36)48-33(25)46-31)63-41(5,57-11)42(6,58-12)64-28/h13-14,51-52H,15-18H2,1-12H3,(H2,43,44,45,46,47,48,49,50)/t37-,38-,39-,40-,41-,42-/m1/s1
SMILES Code: C[C@@]([C@](C)(OC)O1)(OC)OC(/C2=N/C3=N/C(C4=C3O[C@@](C)(OC)[C@](C)(OC)O4)=N\5)=C1/C(N2)=N/C(C6=C/7C(CCO)=CC=C6CCO)=NC7=N/C8=C(O[C@@](C)(OC)[C@](C)(OC)O9)C9=C5N8
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Porphyrazines (Pzs) are tetrapyrrolic macrocycles made by a synthetic pathway that allows for heteroatom substitution. (S, N, O) in the β-pyrrole positions. Heteroatom functionalized Pzs have been recently examined as PDT agents, with some N atom functionalized macrocycles exhibiting remarkably high singlet oxygen quantum yields (ΦΔ > 50%). Pz 285 showed poor singlet oxygen quantum yield (ΦΔ < 1%).
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 890.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Discovery of the Antitumor Effects of a Porphyrazine Diol (Pz 285) in MDA-MB-231 Breast Tumor Xenograft Models in Mice
Irawati K. Kandela, Katherine J. McAuliffe, Lauren E. Cochran, Anthony G. M. Barrett, Brian M. Hoffman, Andrew P. Mazar, and Evan R. Trivedi Publication Date (Web): June 29, 2017 (Letter). DOI: 10.1021/acsmedchemlett.7b00063