WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561041
CAS#: 87272-20-6 (free acid)
Description: MEDICA16 is a GPR40 agonist. MEDICA 16 is a β,β'-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat.
Hodoodo Cat#: H561041
Name: MEDICA16
CAS#: 87272-20-6 (free acid)
Chemical Formula: C20H36Na2O4
Exact Mass: 0.00
Molecular Weight: 386.484
Elemental Analysis: C, 62.16; H, 9.39; Na, 11.90; O, 16.56
Synonym: MEDICA 16; MEDICA-16; MEDICA16
IUPAC/Chemical Name: Disodium 3,3,14,14-Tetramethylhexadecanedioate
InChi Key: OPKBTZAHVBZFNW-UHFFFAOYSA-L
InChi Code: InChI=1S/C20H38O4.2Na/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24;;/h5-16H2,1-4H3,(H,21,22)(H,23,24);;/q;2*+1/p-2
SMILES Code: O=C([O-])CC(C)(C)CCCCCCCCCCC(C)(C)CC([O-])=O.[Na+].[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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| In vitro activity: | |
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The following data is based on the product molecular weight 386.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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5: Sun Q, Hirasawa A, Hara T, Kimura I, Adachi T, Awaji T, Ishiguro M, Suzuki T, Miyata N, Tsujimoto G. Structure-activity relationships of GPR120 agonists based on a docking simulation. Mol Pharmacol. 2010 Nov;78(5):804-10. doi: 10.1124/mol.110.066324. Epub 2010 Aug 4. PubMed PMID: 20685848.
6: Shabalina IG, Backlund EC, Bar-Tana J, Cannon B, Nedergaard J. Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism. Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):642-50. doi: 10.1016/j.bbabio.2008.04.038. Epub 2008 May 1. PubMed PMID: 18489899.
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