WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561264
CAS#: 1635405-90-1 (racemic)
Description: 1D-2 is a highly potent and exquisitely selective inhibitor of the mesenchymal-epithelial transition factor (c-Met) protein kinase. Aberrant c-Met activation has been implicated in multiple tumor oncogenic processes and drug resistance.
Hodoodo Cat#: H561264
Name: 1D-2
CAS#: 1635405-90-1 (racemic)
Chemical Formula: C20H16FN7
Exact Mass: 373.15
Molecular Weight: 373.400
Elemental Analysis: C, 64.33; H, 4.32; F, 5.09; N, 26.26
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Synonym: 1D-2; 1D 2; 1D2
IUPAC/Chemical Name: (R)-7-fluoro-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-b]pyrazin-1-yl)ethyl)quinoline
InChi Key: SXWUXXWVCWEUTA-GFCCVEGCSA-N
InChi Code: InChI=1S/C20H16FN7/c1-12(15-6-13-4-3-5-22-17(13)7-16(15)21)28-11-24-19-20(28)26-18(9-23-19)14-8-25-27(2)10-14/h3-12H,1-2H3/t12-/m1/s1
SMILES Code: C[C@H](C1=C(F)C=C2N=CC=CC2=C1)N3C=NC4=NC=C(C5=CN(C)N=C5)N=C43
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 373.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Zhao F, Zhang J, Zhang L, Hao Y, Shi C, Xia G, Yu J, Liu Y. Discovery and optimization of a series of imidazo[4,5-b]pyrazine derivatives as highly potent and exquisitely selective inhibitors of the mesenchymal-epithelial transition factor (c-Met) protein kinase. Bioorg Med Chem. 2016 Sep 15;24(18):4281-90. doi: 10.1016/j.bmc.2016.07.019. Epub 2016 Jul 12. PubMed PMID: 27448775.