WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H571233
CAS#: 56-10-0
Description: beta-Aminoethylisothiuronium Bromide is a radiation-protective agent that can inhibit DNA damage by binding to the DNA. It also increases the susceptibility of blood cells to complement-mediated lysis.
Hodoodo Cat#: H571233
Name: beta-Aminoethylisothiuronium Bromide
CAS#: 56-10-0
Chemical Formula: C3H11Br2N3S
Exact Mass: 278.90
Molecular Weight: 281.010
Elemental Analysis: C, 12.82; H, 3.95; Br, 56.87; N, 14.95; S, 11.41
This product is not in stock, which may be available by custom synthesis.
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Synonym: beta-Aminoethylisothiuronium Bromide
IUPAC/Chemical Name: Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide
InChi Key: XDVMCVGTDUKDHL-UHFFFAOYSA-N
InChi Code: InChI=1S/C3H9N3S.2BrH/c4-1-2-7-3(5)6;;/h1-2,4H2,(H3,5,6);2*1H
SMILES Code: NC(SCCN)=N.[H]Br.[H]Br
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 281.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Gabrilovich IM, Seleznev AF. [Protective effect of S-beta-aminoethylisothiuronium bromide on the T2 phage]. Radiobiologiia. 1965;5(2):314-5. Russian. PubMed PMID: 5871975.
2: BENSON RE, MICHAELSON SM, DOWNS WL, MAYNARD EA, SCOTT JK, HODGE HC, HOWLAND JW. Toxicological and radioprotection studies on S,beta-aminoethylisothiuronium bromide (AET). Radiat Res. 1961 Nov;15:561-72. PubMed PMID: 13867361.
3: Glembotskii YL, Grozdova TY. Experiments on the antimutagenic effect of AET (beta-aminoethylisothiuronium bromide) in Drosophila melanogaster. Sov Genet. 1973 Aug;7(2):213-20. PubMed PMID: 4216077.
4: BYCHKOVSKAIA IB, NOVOSELOVA GS. [ON THE EVALUATION OF THE RADIOPROTECTIVE ACTION OF BETA-AMINOETHYLISOTHIURONIUM (AET)]. Radiobiologiia. 1964;4:234-8. Russian. PubMed PMID: 14152986.
5: Naqvi S, Kumar KS, Venkitasubramanian TA. Effect of beta-aminoethylisothiuronium-bromide-hydrobromide on the acetate-1-14C incorporation into tissue lipids of irradiated rats. Experientia. 1968 Sep 15;24(9):891-2. PubMed PMID: 5709022.
6: Basu SK, Srinivasan MN, Chuttani K, George S. Radioprotection of spleen by a combination of 5-hydroxy-L-tryptophan and 2-aminoethylisothiuronium bromide hydrobromide in lethally irradiated rats. Strahlenther Onkol. 1992 Jul;168(7):427-31. PubMed PMID: 1496455.
7: PISAREVSKII AN, SELEZNEV AF. [ON A POSSIBLE MECHANISM OF PROTECTIVE PROPERTIES OF S-BETS-AMINOETHYLISOTHIURONIUM BROMIDE]. Biofizika. 1965;10:179-81. Russian. PubMed PMID: 14332035.
8: KERKIS IuIa, NAUMENKO IuN. [RADIOPROTECTIVE ACTION OF BETA-AMINOETHYLISOTHIURONIUM BR.HBR (AET) ON THE HEREDITARY STRUCTURES OF VARIOUS MAMMALIAN TISSUES]. Radiobiologiia. 1964;4:221-5. Russian. PubMed PMID: 14152984.
9: Kono A, Matsushima Y. Radiation-inactivation of aspartate amino transferase and its protection by 2-mercaptoethylamine and 2-aminoethylisothiuronium bromide. Chem Pharm Bull (Tokyo). 1977 Jan;25(1):147-50. PubMed PMID: 852080.
10: SMIRNOVA IB. [Effect of aminoethylisothiuronium bromide HBr on rakiation injuries of the mucous membrane of the small intestine]. Radiobiologiia. 1962;2:768-72. Russian. PubMed PMID: 13993093.
11: CONDIT PT, LEVY AH, SHNIDER BI, OVIEDO RG. Some effects of S,2-aminoethylisothiuronium bromide hydrobromide (AET) in man. Cancer. 1960 Jul-Aug;13:842-9. PubMed PMID: 13811473.
12: DISTEFANO V, LEARY DE, LITTLE KD. The pharmacological effects of some congeners of 2-aminoethylisothiuronium bromide (AET). J Pharmacol Exp Ther. 1959 Jun;126(2):158-63. PubMed PMID: 13665523.
13: Ozawa H, Kubota K, Hara Y. [Pharmacological action of 2-aminoethylisothiuronium (AET) derivatives. VI. Pharmacological action of 2-aminoethyl-1-p-chlorophenyl-isothiuronium bromide (AEPCIT)]. Yakugaku Zasshi. 1968 Oct;88(10):1352-5. Japanese. PubMed PMID: 5751317.
14: DISTEFANO V, KORN PS, LEARY DE. A comparison of the pharmacological effects of some compounds related to 2-aminoethylisothiuronium bromide hydrobromide (AET). Radiat Res. 1963 Feb;18:177-85. PubMed PMID: 14028067.
15: SHAPIRO B. The metabolism of the radiation protective agent 2-aminoethylisothiuronium bromide hydrobromide in mice and its alteration by radiation. Tech Doc Rep SAMTDR USAF Sch Aerosp Med. 1959 Dec;59:30:1-12. PubMed PMID: 13856347.
16: Phan Van Duyet, Nejtek VM, Dienstbier Z. [The effect of 2-aminoethylisothiuronium bromide-hydrobromide on 22Na transport in the isolated small intestine of normal and irradiated rats]. Strahlentherapie. 1967 Mar;132(3):448-53. German. PubMed PMID: 5588050.
17: Basu SK, Srinivasan MN, Chuttani K, George S. Protection to glycolysis by a combination of 5-hydroxy-L-tryptophan and 2-aminoethylisothiuronium bromide hydrobromide in lethally irradiated rats. Indian J Exp Biol. 1992 Sep;30(9):785-7. PubMed PMID: 1478714.
18: Filimonova MV, Proskuriakov SIa, Shevchenko LI, Shevchuk AS, Lushnikova GA, Makarchuk VM, Arzamastsev EV, Laba VI, Malinovskaia KI, Levitskaia EL. [Radioprotective properties of isothiourea derivatives with NO-inhibitory mechanism of action]. Radiats Biol Radioecol. 2012 Nov-Dec;52(6):593-601. Russian. PubMed PMID: 23516890.
19: Ozawa H, Hara Y. [Pharmacological actions of 2-aminoethylisothiuronium (AET) derivatives. V. Tachyphylaxis to 2-(2-diethylaminoethyl)-1-phenylisothiuronium bromide hydobromide (DEPT)]. Yakugaku Zasshi. 1968 Oct;88(10):1270-6. PubMed PMID: 5751302.
20: Davydov BI. [Quantitative evaluation (according to the toxic effect) of the absorption and elimination of cystaphos, S,beta-aminoethylisothiuronium and 5-methoxytryptamine with intraperitoneal and intragastric injections]. Radiobiologiia. 1972 Jan-Feb;12(1):136-40. Russian. PubMed PMID: 5040081.
