PF9238
featured

Notice: hodoodo.ccom website will be shut down by June 30, 2025. Its business will be taken care by MedKoo Bioscience. Please visit medkoo.com for your research need.

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H571262

CAS#: 1621585-17-8

Description: PF9238 is a beta-secretase I inhibitor. Treatment with PF9238 results in the accumulation of autofluorescent granules in the retinas. PF9238 has a CatD potency of 12 uM in vivo.

Chemical Structure

img
PF9238
CAS# 1621585-17-8
Instruction

Theoretical Analysis

Hodoodo Cat#: H571262
Name: PF9238
CAS#: 1621585-17-8
Chemical Formula: C18H19F2N3O2S
Exact Mass: 379.12
Molecular Weight: 379.430
Elemental Analysis: Elemental Analysis: C, 56.98; H, 5.05; F, 10.01; N, 11.07; O, 8.43; S, 8.45

Price and Availability

Size Price Availability Quantity
5mg USD 280 2 Weeks
Bulk inquiry

Synonym: PF9238; PF-9238; PF 9238; PF-06649283; PF06649283; PF 06649283;

IUPAC/Chemical Name: (4R,4aR,6R,8aS)-8a-(2,4-difluorophenyl)-4-methyl-6-(3-methylisoxazol-5-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine

InChi Key: HVEVDFRWOQHAPJ-CKMNQQOVSA-N

InChi Code: InChI=1S/C18H19F2N3O2S/c1-9-5-16(25-23-9)15-7-13-10(2)26-17(21)22-18(13,8-24-15)12-4-3-11(19)6-14(12)20/h3-6,10,13,15H,7-8H2,1-2H3,(H2,21,22)/t10-,13+,15-,18-/m1/s1

SMILES Code: [H][C@@]12[C@@](CO[C@@H](C3=CC(C)=NO3)C2)(C4=CC=C(F)C=C4F)N=C(N)S[C@@H]1C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 379.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Schwaid AG, Cornella-Taracido I. Causes and Significance of Increased Compound Potency in Cellular or Physiological Contexts. J Med Chem. 2017 Aug 18. doi: 10.1021/acs.jmedchem.7b00762. [Epub ahead of print] PubMed PMID: 28820267.