WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561382
CAS#: 18623-44-4
Description: iCRT5 is a cell-permeable β-catenin-responsive transcription (CRT) inhibitor. iCRT5 disrupts the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin.
Hodoodo Cat#: H561382
Name: iCRT5
CAS#: 18623-44-4
Chemical Formula: C16H17NO5S2
Exact Mass: 367.05
Molecular Weight: 367.430
Elemental Analysis: C, 52.30; H, 4.66; N, 3.81; O, 21.77; S, 17.45
This product is not in stock, which may be available by custom synthesis.
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Synonym: iCRT5; iCRT-5; iCRT 5;
IUPAC/Chemical Name: (Z)-4-(5-(3,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid
InChi Key: IJWKSBPTJQMUHJ-LCYFTJDESA-N
InChi Code: InChI=1S/C16H17NO5S2/c1-21-11-6-5-10(8-12(11)22-2)9-13-15(20)17(16(23)24-13)7-3-4-14(18)19/h5-6,8-9H,3-4,7H2,1-2H3,(H,18,19)/b13-9-
SMILES Code: O=C(O)CCCN(C/1=O)C(SC1=C/C2=CC=C(OC)C(OC)=C2)=S
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 367.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |