WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561429
CAS#: 1152314-49-2
Description: BFF122 is a kynurenine aminotransferase II (KAT II) inhibitor. KAT II catalyzes transamination of L-kynurenine in astrocytes, a precursor to kynurenic acid (KYNA) that acts as a neuroactive metabolite.
Hodoodo Cat#: H561429
Name: BFF122
CAS#: 1152314-49-2
Chemical Formula: C17H19FN4O4
Exact Mass: 362.14
Molecular Weight: 362.360
Elemental Analysis: C, 56.35; H, 5.29; F, 5.24; N, 15.46; O, 17.66
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Synonym: BFF122; BFF 122; BFF-122; BF5;
IUPAC/Chemical Name: (S)-9-(4-Amino-piperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid
InChi Key: ICQVSZFWVUBYSI-VIFPVBQESA-N
InChi Code: InChI=1S/C17H19FN4O4/c1-9-8-26-16-13-10(15(23)11(17(24)25)7-22(9)13)6-12(18)14(16)20-2-4-21(19)5-3-20/h6-7,9H,2-5,8,19H2,1H3,(H,24,25)/t9-/m0/s1
SMILES Code: O=C(C(C1=O)=CN2[C@@H](C)COC3=C2C1=CC(F)=C3N4CCN(N)CC4)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 362.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Alkondon M, Pereira EF, Eisenberg HM, Kajii Y, Schwarcz R, Albuquerque EX. Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain. J Pharmacol Exp Ther. 2011 Jun;337(3):572-82. doi: 10.1124/jpet.110.177386. Epub 2011 Jan 26. PubMed PMID: 21270133; PubMed Central PMCID: PMC3101010.
2: Rossi F, Valentina C, Garavaglia S, Sathyasaikumar KV, Schwarcz R, Kojima S, Okuwaki K, Ono S, Kajii Y, Rizzi M. Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement. J Med Chem. 2010 Aug 12;53(15):5684-9. doi: 10.1021/jm100464k. PubMed PMID: 20684605; PubMed Central PMCID: PMC3929320.