WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530945
CAS#: 1333207-63-8 (HCl)
Description: SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected.
Hodoodo Cat#: H530945
Name: SAR-7334 HCl
CAS#: 1333207-63-8 (HCl)
Chemical Formula: C21H24Cl3N3O
Exact Mass: 0.00
Molecular Weight: 440.793
Elemental Analysis: C, 57.22; H, 5.49; Cl, 24.13; N, 9.53; O, 3.63
Related CAS #: 1333210-07-3 (free base) 1333207-63-8 (HCl)
Synonym: SAR-7334; SAR 7334; SAR7334. SAR-7334 HCl, SAR-7334 hydrochloride
IUPAC/Chemical Name: 4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile dihydrochloride
InChi Key: LFMYIKNZNTZSJX-IQJQELQDSA-N
InChi Code: InChI=1S/C21H22ClN3O.2ClH/c22-18-10-14(12-23)7-8-20(18)26-21-17-6-2-1-4-15(17)11-19(21)25-9-3-5-16(24)13-25;;/h1-2,4,6-8,10,16,19,21H,3,5,9,11,13,24H2;2*1H/t16-,19-,21-;;/m1../s1
SMILES Code: N#CC1=CC=C(O[C@H]2[C@H](N3C[C@H](N)CCC3)CC4=C2C=CC=C4)C(Cl)=C1.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 440.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Maier T, Follmann M, Hessler G, Kleemann HW, Hachtel S, Fuchs B, Weissmann N,
Linz W, Schmidt T, Löhn M, Schroeter K, Wang L, Rütten H, Strübing C. Discovery
and pharmacological characterization of a novel potent inhibitor of
diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol. 2015
Jul;172(14):3650-60. doi: 10.1111/bph.13151. Epub 2015 May 19. PubMed PMID:
25847402; PubMed Central PMCID: PMC4507166.
2: Ilatovskaya DV, Palygin O, Levchenko V, Endres BT, Staruschenko A. The Role of
Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci
Rep. 2017 Mar 22;7(1):299. doi: 10.1038/s41598-017-00406-2. PubMed PMID:
28331185; PubMed Central PMCID: PMC5428415.
3: Chauvet S, Jarvis L, Chevallet M, Shrestha N, Groschner K, Bouron A.
Pharmacological Characterization of the Native Store-Operated Calcium Channels of
Cortical Neurons from Embryonic Mouse Brain. Front Pharmacol. 2016 Dec 12;7:486.
doi: 10.3389/fphar.2016.00486. eCollection 2016. Erratum in: Front Pharmacol.
2017 Mar 22;8:152. PubMed PMID: 28018223; PubMed Central PMCID: PMC5149554.
