WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561520
CAS#: 1070966-96-9
Description: BKM1644 effectively inhibits the proliferation of metastatic, castration-resistant PCa (mCRPC) cells.
Hodoodo Cat#: H561520
Name: BKM1644
CAS#: 1070966-96-9
Chemical Formula: C34H37Cl2F5N2O9P2
Exact Mass: 844.13
Molecular Weight: 845.510
Elemental Analysis: C, 48.30; H, 4.41; Cl, 8.39; F, 11.23; N, 3.31; O, 17.03; P, 7.33
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Synonym: BKM1644; BKM-1644; BKM 1644;
IUPAC/Chemical Name: tetraethyl ((3-(4-((2,6-dichlorobenzyl)oxy)phenyl)-2-(3-(perfluorophenyl)acrylamido)propanamido)methylene)(R,E)-bis(phosphonate)
InChi Key: BUVQOTXMGBNZPM-ZMNABIIRSA-N
InChi Code: InChI=1S/C34H37Cl2F5N2O9P2/c1-5-49-53(46,50-6-2)34(54(47,51-7-3)52-8-4)43-33(45)26(42-27(44)17-16-22-28(37)30(39)32(41)31(40)29(22)38)18-20-12-14-21(15-13-20)48-19-23-24(35)10-9-11-25(23)36/h9-17,26,34H,5-8,18-19H2,1-4H3,(H,42,44)(H,43,45)/b17-16+/t26-/m1/s1
SMILES Code: O=C(N[C@H](CC1=CC=C(OCC2=C(Cl)C=CC=C2Cl)C=C1)C(NC(P(OCC)(OCC)=O)P(OCC)(OCC)=O)=O)/C=C/C3=C(F)C(F)=C(F)C(F)=C3F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 845.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Zhang S, Gera L, Mamouni K, Li X, Chen Z, Kucuk O, Wu D. Inhibition of skeletal growth of human prostate cancer by the combination of docetaxel and BKM1644: an aminobisphosphonate derivative. Oncotarget. 2016 May 10;7(19):27489-98. doi: 10.18632/oncotarget.8481. PubMed PMID: 27050371; PubMed Central PMCID: PMC5053666.