Tamsulosin HCl
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Hodoodo CAT#: H561623

CAS#: 106463-17-6

Description: Tamsulosin HCl is a potent and selective alpha1A-adrenoceptor antagonist. It is used to treat symptomatic benign prostatic hyperplasia (BPH), help with the passage of kidney stones, and for urinary retention along with other measures.

Chemical Structure

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Tamsulosin HCl
CAS# 106463-17-6
Instruction

Theoretical Analysis

Hodoodo Cat#: H561623
Name: Tamsulosin HCl
CAS#: 106463-17-6
Chemical Formula: C19H27ClN2O4S
Exact Mass: 0.00
Molecular Weight: 414.940
Elemental Analysis: C, 55.00; H, 6.56; Cl, 8.54; N, 6.75; O, 15.42; S, 7.73

Price and Availability

Size Price Availability Quantity
100mg USD 220
1g USD 650
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Synonym: Tamsulosin HCl; Tamsulosin Hydrochloride; Pradif; Flomax; Omnic;

IUPAC/Chemical Name: 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-benzenesulfonamide hydrochloride

InChi Key: YBJXJHQQILTSMO-XFULWGLBSA-N

InChi Code: InChI=1S/C19H26N2O4S.ClH/c1-3-24-18-6-4-5-7-19(18)25-13-12-21-15(2)14-16-8-10-17(11-9-16)26(20,22)23;/h4-11,15,21H,3,12-14H2,1-2H3,(H2,20,22,23);1H/t15-;/m1./s1

SMILES Code: O=S(C1=CC=C(C[C@H](NCCOC2=CC=CC=C2OCC)C)C=C1)(N)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 414.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fossler MJ, Collins DA, Thompson MM, Nino A, Bianco JJ, Chetty D. Pharmacokinetic bioequivalence studies of a fixed-dose combination of tamsulosin and dutasteride in healthy volunteers. Clin Drug Investig. 2014 May;34(5):335-49. doi: 10.1007/s40261-014-0179-0. PubMed PMID: 24615171.

2: Hodges LA, Sime KA, Creech LA, Connolly SM, Barclay ST, Kwon MC, Jeon BJ, Shim SM, Wang HS, Stevens HN, Park JS. Pharmacoscintigraphy confirms consistent tamsulosin release from a novel triple-layered tablet. Int J Pharm. 2013 Sep 15;454(1):41-6. doi: 10.1016/j.ijpharm.2013.06.065. Epub 2013 Jul 5. PubMed PMID: 23834829.

3: Shelbaia A, Elsaied WM, Elghamrawy H, Abdullah A, Salaheldin M. Effect of selective alpha-blocker tamsulosin on erectile function in patients with lower urinary tract symptoms due to benign prostatic hyperplasia. Urology. 2013 Jul;82(1):130-5. doi: 10.1016/j.urology.2013.03.026. Epub 2013 May 25. PubMed PMID: 23711438.

4: Kumar GS, Kumar BS. Stability-Indicating RP-HPLC Method for Determination of Tamsulosin HCL in Pharmaceutical Dosage Form. J Basic Clin Pharm. 2012 Mar;3(2):255-60. Epub 2012 May 15. PubMed PMID: 24826033; PubMed Central PMCID: PMC3979258.

5: Kumari R, Dash PP, Lal VK, Mishra A, Murthy PN. RP - HPLC method for the estimation of Tamsulosin Hydrochloride in Tablet Dosage Form. Indian J Pharm Sci. 2010 Nov;72(6):785-7. doi: 10.4103/0250-474X.84596. PubMed PMID: 21969754; PubMed Central PMCID: PMC3178983.

6: Korstanje C, Krauwinkel W, van Doesum-Wolters FL. Tamsulosin shows a higher unbound drug fraction in human prostate than in plasma: a basis for uroselectivity? Br J Clin Pharmacol. 2011 Aug;72(2):218-25. doi: 10.1111/j.1365-2125.2010.03870.x. PubMed PMID: 21745239; PubMed Central PMCID: PMC3162651.

7: Kim SO, Hwang EC, Oh KJ, Kwon D, Park K, Ryu SB. Efficacy and safety of combined therapy with tamsulosin and tolterodine in female patients with a maximal flow rate less than 12 ml/s. Int Urogynecol J. 2011 Oct;22(10):1287-91. doi: 10.1007/s00192-011-1453-9. Epub 2011 May 27. PubMed PMID: 21617983.

8: Park JS, Shim JY, Park JS, Lee MJ, Kang JM, Lee SH, Kwon MC, Choi YW, Jeong SH. Formulation variation and in vitro-in vivo correlation for a rapidly swellable three-layered tablet of tamsulosin HCl. Chem Pharm Bull (Tokyo). 2011;59(5):529-35. PubMed PMID: 21532187.

9: Troost J, Tatami S, Tsuda Y, Mattheus M, Mehlburger L, Wein M, Michel MC. Effects of strong CYP2D6 and 3A4 inhibitors, paroxetine and ketoconazole, on the pharmacokinetics and cardiovascular safety of tamsulosin. Br J Clin Pharmacol. 2011 Aug;72(2):247-56. doi: 10.1111/j.1365-2125.2011.03988.x. PubMed PMID: 21496064; PubMed Central PMCID: PMC3162654.

10: Tsuda Y, Tatami S, Yamamura N, Tadayasu Y, Sarashina A, Liesenfeld KH, Staab A, Schäfer HG, Ieiri I, Higuchi S. Population pharmacokinetics of tamsulosin hydrochloride in paediatric patients with neuropathic and non-neuropathic bladder. Br J Clin Pharmacol. 2010 Jul;70(1):88-101. doi: 10.1111/j.1365-2125.2010.03662.x. PubMed PMID: 20642551; PubMed Central PMCID: PMC2909811.

11: Chang HS, Park CH, Kim DK, Park JK, Hong SJ, Chung BH, Lee JG, Kim CS, Lee KS, Kim JC. Assessment of patient-reported outcome of patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia and treated with tamsulosin HCl in Korea. Urology. 2010 May;75(5):1156-61. doi: 10.1016/j.urology.2009.09.010. Epub 2009 Nov 14. PubMed PMID: 19914692.

12: Ozkan SA, Uslu B, Aboul-Enein HY. Voltammetric investigation of Tamsulosin. Talanta. 2003 Oct 17;61(2):147-56. doi: 10.1016/S0039-9140(03)00248-0. PubMed PMID: 18969173.

13: Kim MS, Jun SW, Lee S, Lee TW, Park JS, Hwang SJ. The influence of Surelease and sodium alginate on the in-vitro release of tamsulosin hydrochloride in pellet dosage form. J Pharm Pharmacol. 2005 Jun;57(6):735-42. PubMed PMID: 15969928.

14: Nieminen T, Ylitalo R, Kööbi T, Ylitalo P, Kähönen M. Effects of adrenoceptor blocking drugs on cardiovascular responsiveness to passive orthostasis: a placebo-controlled double-blind study. Arzneimittelforschung. 2005;55(4):205-11. PubMed PMID: 15901043.

15: Prosnitz RG, Schneider L, Manola J, Rocha S, Loffredo M, Lopes L, D'Amico AV. Tamsulosin palliates radiation-induced urethritis in patients with prostate cancer: results of a pilot study. Int J Radiat Oncol Biol Phys. 1999 Oct 1;45(3):563-6. PubMed PMID: 10524406.

16: van Hoogdalem EJ, Soeishi Y, Matsushima H, Higuchi S. Disposition of the selective alpha1A-adrenoceptor antagonist tamsulosin in humans: comparison with data from interspecies scaling. J Pharm Sci. 1997 Oct;86(10):1156-61. PubMed PMID: 9344174.

17: García-Sáinz JA, Romero-Avila MT, González-Espinosa C. Coexpression of alpha 1A- and alpha 1B-adrenoceptors in the liver of the rhesus monkey (Macaca mulatta). Eur J Pharmacol. 1996 Sep 12;311(2-3):277-83. PubMed PMID: 8891610.

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19: Yazawa H, Honda K. Alpha 1-adrenoceptor subtype in the rat prostate is preferentially the alpha 1A type. Jpn J Pharmacol. 1993 Jul;62(3):297-304. PubMed PMID: 8105125.

20: Yazawa H, Takanashi M, Sudoh K, Inagaki O, Honda K. Characterization of [3H]YM617, R-(-)-5-[2-[[2[ethoxyring(n)-3H](o-ethoxyphenoxy)ethyl]amino]- propyl]-2-methoxybenzenesulfonamide HCl, a potent and selective alpha-1 adrenoceptor radioligand. J Pharmacol Exp Ther. 1992 Oct;263(1):201-6. PubMed PMID: 1357156.