WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H555105
CAS#: 1259028-99-3
Description: BTT-3033 is a α2β1 integrin inhibitor. BTT-3033 blocks platelet attachment under flow (90 dynes/cm(2)). The action of BTT-3033, unlike that of BTT-3034, was dependent on Tyr-285.
Hodoodo Cat#: H555105
Name: BTT-3033
CAS#: 1259028-99-3
Chemical Formula: C23H20FN5O3S
Exact Mass: 465.13
Molecular Weight: 465.503
Elemental Analysis: C, 59.35; H, 4.33; F, 4.08; N, 15.05; O, 10.31; S, 6.89
Synonym: BTT-3033; BTT 3033; BTT3033.
IUPAC/Chemical Name: 1-(4-Fluorophenyl)-N-methyl-N-(4-(3-phenylureido)phenyl)-1H-pyrazole-4-sulfonamide
InChi Key: NSLIQOPYDUKWTA-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H20FN5O3S/c1-28(33(31,32)22-15-25-29(16-22)21-11-7-17(24)8-12-21)20-13-9-19(10-14-20)27-23(30)26-18-5-3-2-4-6-18/h2-16H,1H3,(H2,26,27,30)
SMILES Code: O=S(C1=CN(C2=CC=C(F)C=C2)N=C1)(N(C)C3=CC=C(NC(NC4=CC=CC=C4)=O)C=C3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: The interaction between α2β1 integrin (GPIa/IIa, VLA-2) and vascular collagen is one of the initiating events in thrombus formatio
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 465.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Nissinen L, Koivunen J, Käpylä J, Salmela M, Nieminen J, Jokinen J, Sipilä K,
Pihlavisto M, Pentikäinen OT, Marjamäki A, Heino J. Novel α2β1 integrin
inhibitors reveal that integrin binding to collagen under shear stress conditions
does not require receptor preactivation. J Biol Chem. 2012 Dec
28;287(53):44694-702. doi: 10.1074/jbc.M111.309450. Epub 2012 Nov 6. PubMed PMID:
23132859; PubMed Central PMCID: PMC3531784.