ORG-20599

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H527008

CAS#: 156685-94-8

Description: ORG-20599 is a novel water-soluble modulator of GABAA receptor.

Chemical Structure

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ORG-20599
CAS# 156685-94-8
Instruction

Theoretical Analysis

Hodoodo Cat#: H527008
Name: ORG-20599
CAS#: 156685-94-8
Chemical Formula: C25H40ClNO3
Exact Mass: 437.27
Molecular Weight: 438.049
Elemental Analysis: C, 68.55; H, 9.20; Cl, 8.09; N, 3.20; O, 10.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ORG-20599; ORG20599; ORG20599

IUPAC/Chemical Name: 2beta,3alpha,5alpha-21-Chloro-3-hydroxy-2-(4-morpholinyl)pregnan-20-one

InChi Key: NZFNABGZEQPYBX-PMBZPZLSSA-N

InChi Code: InChI=1S/C25H40ClNO3/c1-24-8-7-19-17(18(24)5-6-20(24)23(29)15-26)4-3-16-13-22(28)21(14-25(16,19)2)27-9-11-30-12-10-27/h16-22,28H,3-15H2,1-2H3/t16-,17-,18-,19-,20+,21-,22-,24-,25-/m0/s1

SMILES Code: C[C@@]12[C@@H](C(CCl)=O)CC[C@@]1([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)[C@@H](N5CCOCC5)C[C@]4(C)[C@@]3([H])CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 438.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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5: Anderson A, Boyd AC, Byford A, Campbell AC, Gemmell DK, Hamilton NM, Hill DR, Hill-Venning C, Lambert JJ, Maidment MS, May V, Marshall RJ, Peters JA, Rees DC, Stevenson D, Sundaram H. Anesthetic activity of novel water-soluble 2 beta-morpholinyl steroids and their modulatory effects at GABAA receptors. J Med Chem. 1997 May 23;40(11):1668-81. PubMed PMID: 9171876.

6: Hill-Venning C, Peters JA, Callachan H, Lambert JJ, Gemmell DK, Anderson A, Byford A, Hamilton N, Hill DR, Marshall RJ, Campbell AC. The anaesthetic action and modulation of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology. 1996;35(9-10):1209-22. PubMed PMID: 9014136.