WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H527027
CAS#: 847928-32-9
Description: 1G244 is a novel potent and selective DPP8/9 inhibitor.
Hodoodo Cat#: H527027
Name: 1G244
CAS#: 847928-32-9
Chemical Formula: C29H30F2N4O2
Exact Mass: 504.23
Molecular Weight: 504.582
Elemental Analysis: C, 69.03; H, 5.99; F, 7.53; N, 11.10; O, 6.34
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: 1G244; 1G-244; 1G 244
IUPAC/Chemical Name: (S)-2-Amino-4-{4-[bis-(4-fluorophenyl)-methyl]piperazin-1-yl}-1-(1,3-dihydro-isoindol-2-yl)-butane-1,4-dione
InChi Key: ZKIQFLSGMMYCGS-SANMLTNESA-N
InChi Code: InChI=1S/C29H30F2N4O2/c30-24-9-5-20(6-10-24)28(21-7-11-25(31)12-8-21)34-15-13-33(14-16-34)27(36)17-26(32)29(37)35-18-22-3-1-2-4-23(22)19-35/h1-12,26,28H,13-19,32H2/t26-/m0/s1
SMILES Code: O=C(N1CC2=C(C=CC=C2)C1)[C@@H](N)CC(N3CCN(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 504.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Batista PSC, Menezes CB, Carvalho AJ, Portugal AF, Bastos EA, Cardoso MJ, Santos CV, Julio MPM. Performance of grain sorghum hybrids under drought stress using GGE biplot analyses. Genet Mol Res. 2017 Sep 21;16(3). doi: 10.4238/gmr16039761. PubMed PMID: 28973741.
2: Gabrilovac J, Čupić B, Zapletal E, Kraus O, Jakić-Razumović J. Dipeptidyl peptidase 9 (DPP9) in human skin cells. Immunobiology. 2017 Feb;222(2):327-342. doi: 10.1016/j.imbio.2016.09.007. Epub 2016 Sep 19. PubMed PMID: 27682012.
3: Han R, Wang X, Bachovchin W, Zukowska Z, Osborn JW. Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation. Sci Rep. 2015 Aug 5;5:12348. doi: 10.1038/srep12348. PubMed PMID: 26242871; PubMed Central PMCID: PMC4525143.
4: Matheeussen V, Waumans Y, Martinet W, Van Goethem S, Van der Veken P, Scharpé S, Augustyns K, De Meyer GR, De Meester I. Dipeptidyl peptidases in atherosclerosis: expression and role in macrophage differentiation, activation and apoptosis. Basic Res Cardiol. 2013 May;108(3):350. doi: 10.1007/s00395-013-0350-4. Epub 2013 Apr 23. PubMed PMID: 23608773.
5: Wu JJ, Tang HK, Yeh TK, Chen CM, Shy HS, Chu YR, Chien CH, Tsai TY, Huang YC, Huang YL, Huang CH, Tseng HY, Jiaang WT, Chao YS, Chen X. Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem Pharmacol. 2009 Jul 15;78(2):203-10. doi: 10.1016/j.bcp.2009.03.032. Epub 2009 Apr 11. PubMed PMID: 19439267.