WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561741
CAS#: 106351-79-5
Description: Butyryltimolol is a lipophilic ester prodrug of timolol, a beta adrenergic blocer with antihypertensive and hemodynamic properties.
Hodoodo Cat#: H561741
Name: Butyryltimolol
CAS#: 106351-79-5
Chemical Formula: C17H30N4O4S
Exact Mass: 386.20
Molecular Weight: 386.510
Elemental Analysis: C, 52.83; H, 7.82; N, 14.50; O, 16.56; S, 8.29
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Synonym: Butyryltimolol; Butyryl timolol; Butyryl-timolol;
IUPAC/Chemical Name: [(2S)-1-(tert-Butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-yl] butanoate
InChi Key: IGJCFKQCZRWRRM-ZDUSSCGKSA-N
InChi Code: InChI=1S/C17H30N4O4S/c1-5-6-14(22)25-13(11-18-17(2,3)4)12-24-16-15(19-26-20-16)21-7-9-23-10-8-21/h13,18H,5-12H2,1-4H3/t13-/m0/s1
SMILES Code: CCCC(O[C@H](COC1=NSN=C1N2CCOCC2)CNC(C)(C)C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 386.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Potter DE, Shumate DJ, Bundgaard H, Lee VH. Ocular and cardiac beta-antagonism by timolol prodrugs, timolol and levobunolol. Curr Eye Res. 1988 Aug;7(8):755-9. PubMed PMID: 2903009.
2: Chang SC, Bundgaard H, Buur A, Lee VH. Low dose O-butyryl timolol improves the therapeutic index of timolol in the pigmented rabbit. Invest Ophthalmol Vis Sci. 1988 Apr;29(4):626-9. PubMed PMID: 3356517.
3: Chang SC, Chien DS, Bundgaard H, Lee VH. Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol. Exp Eye Res. 1988 Jan;46(1):59-69. PubMed PMID: 3342834.
4: Chien DS, Bundgaard H, Lee VH. Influence of corneal epithelial integrity on the penetration of timolol prodrugs. J Ocul Pharmacol. 1988 Summer;4(2):137-46. PubMed PMID: 3171338.
