WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584162
CAS#: 21151-91-7
Description: BFE-55 is derivative of befunolol (a beta-adrenergic partial agonist). BFE-55 interacts with only the high affinity sites in beta-adrenoceptors
Hodoodo Cat#: H584162
Name: BFE-55
CAS#: 21151-91-7
Chemical Formula: C14H19NO3
Exact Mass: 249.14
Molecular Weight: 249.310
Elemental Analysis: C, 67.45; H, 7.68; N, 5.62; O, 19.25
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Synonym: BFE-55; BFE55; BFE 55.
IUPAC/Chemical Name: 2-Propanol, 1-(7-benzofuranyloxy)-3-((1-methylethyl)amino)-
InChi Key: JSBPDRDKVNCRIK-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H19NO3/c1-10(2)15-8-12(16)9-18-13-5-3-4-11-6-7-17-14(11)13/h3-7,10,12,15-16H,8-9H2,1-2H3
SMILES Code: OC(CNC(C)C)COC1=C(OC=C2)C2=CC=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 249.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Takayanagi I, Ogishima M, Koike K, Hisayama T, Hayashida M, Fujii M. Dose difference in beta-adrenergic blockers with intrinsic sympathomimetic action to block beta-adrenoceptors and induce sympathomimetic action. Gen Pharmacol. 1989;20(4):417-9. PubMed PMID: 2568966.
2: Takayanagi I, Koike K, Ogishima M, Hayashida M, Fujii M. Effect of histamine on two different affinity sites in beta-adrenoceptors. Gen Pharmacol. 1989;20(2):219-22. PubMed PMID: 2565848.
3: Koike K, Nakagoshi A, Takayanagi I. A derivative of befunolol, BFE-55, interacts with only the high affinity sites in beta-adrenoceptors. Can J Physiol Pharmacol. 1987 Oct;65(10):2150-3. PubMed PMID: 2827874.
4: Koike K, Takayanagi I. Interactions of befunolol, a beta-adrenergic partial agonist, and its derivatives with high and low affinity sites in beta-adrenoceptors. J Pharmacobiodyn. 1987 Sep;10(9):494-8. PubMed PMID: 2893834.
5: Takayanagi I, Koike K, Nakagoshi A. Interactions of some partial agonists with high and low affinity binding sites in beta-adrenoceptors. Can J Physiol Pharmacol. 1987 Jan;65(1):18-22. PubMed PMID: 2882827.