WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H571461
CAS#: 6164-98-3 (free base)
Description: Chlordimeform is an acaricide used against many organophosphate and carbamate resistant pests. It acts as an uncoupling agent and monoamine oxidase inhibitor.
Hodoodo Cat#: H571461
Name: Chlordimeform
CAS#: 6164-98-3 (free base)
Chemical Formula: C10H13ClN2
Exact Mass: 196.08
Molecular Weight: 196.680
Elemental Analysis: C, 61.07; H, 6.66; Cl, 18.02; N, 14.24
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 6164-98-3 (free base). 19750-95-9 (HCl)
Synonym: Chlordimeform Hydrochloride; Chlordimeform HCl; Spanone; ENT 27567; ENT-27567; ENT27567
IUPAC/Chemical Name: Formamidine, N'-(4-chloro-o-tolyl)-N,N-dimethyl-
InChi Key: STUSTWKEFDQFFZ-KPKJPENVSA-N
InChi Code: InChI=1S/C10H13ClN2/c1-8-6-9(11)4-5-10(8)12-7-13(2)3/h4-7H,1-3H3/b12-7+
SMILES Code: CN(C)/C=N/C1=CC=C(Cl)C=C1C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 196.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Yi X, Han L, Yang H, Fan X, Zhu J, Guo D. [Determination of chlordimeform and its metabolite residues in honey using liquid chromatography-tandem mass spectrometry]. Se Pu. 2010 Jul;28(7):649-53. Chinese. PubMed PMID: 21046782.
2: Landauer MR, Tomlinson WT, Balster RL, MacPhail RC. Some effects of the formamidine pesticide chlordimeform on the behavior of mice. Neurotoxicology. 1984 Summer;5(2):91-100. PubMed PMID: 6542192.
3: Sun S, Zhang K, Lu Y, Zhang H. Theoretical study on the reaction mechanism of chlordimeform with OH radicals. J Mol Model. 2014 Dec;20(12):2519. doi: 10.1007/s00894-014-2519-7. Epub 2014 Nov 20. PubMed PMID: 25411123.
4: Costa LG, Murphy SD. Interaction of the pesticide chlordimeform with adrenergic receptors in mouse brain: an in vitro study. Arch Toxicol. 1987 Feb;59(5):323-7. PubMed PMID: 3034195.
5: Hsu WH, Smith BE, Hollingworth RM. The bradycardic and mydriatic effects of chlordimeform and its demethylated analogs in the rat: antagonism by idazoxan but not by prazosin. Life Sci. 1988;43(23):1897-904. PubMed PMID: 2849009.
6: Chlordimeform. IARC Monogr Eval Carcinog Risk Chem Hum. 1983 Jan;30:61-72. PubMed PMID: 6578191.
7: Ghali GZ, Hollingworth RM. Influence of mixed function oxygenase metabolism on the acute neurotoxicity of the pesticide chlordimeform in mice. Neurotoxicology. 1985 Summer;6(2):215-37. PubMed PMID: 4022452.
8: Kinnamon SC, Klaassen LW, Kammer AE, Claassen D. Octopamine and chlordimeform enhance sensory responsiveness and production of the flight motor pattern in developing and adult moths. J Neurobiol. 1984 Jul;15(4):283-93. PubMed PMID: 6090587.
9: Candura SM, Marraccini P, Costa LG, Manzo L, Rossi A, Coccini T, Tonini M. Calcium entry blockade as a mechanism for chlordimeform-induced inhibition of motor activity in the isolated guinea-pig ileum. Pharmacol Toxicol. 1992 Dec;71(6):426-33. PubMed PMID: 1362268.
10: Robinson CP, Smith PW. Lack of involvement of monoamine oxidase inhibition in the lethality of acute poisoning by chlordimeform. J Toxicol Environ Health. 1977 Oct;3(3):565-8. PubMed PMID: 144803.
11: Leslie C, Reidy GF, Murray M, Stacey NH. Induction of xenobiotic biotransformation by the insecticide chlordimeform, a metabolite 4-chloro-o-toluidine and a structurally related chemical o-toluidine. Biochem Pharmacol. 1988 Jul 1;37(13):2529-35. PubMed PMID: 3390215.
12: Gordon CJ, Long MD, Stead AG. Thermoregulation in mice following acute chlordimeform administration. Toxicol Lett. 1985 Oct;28(1):9-15. PubMed PMID: 4060197.
13: Machin MV, Dingle JH. Ultraviolet determination of chlordimeform in cattle dipping baths and sprays. J Assoc Off Anal Chem. 1977 May;60(3):696-8. PubMed PMID: 858706.
14: Iwan J, Goller D. Metabolic fate of chlordimeform in soil under aerobic, anaerobic, and sterile conditions. Environ Qual Saf Suppl. 1975;3:282-7. PubMed PMID: 1063645.
15: Matsumura F, Beeman RW. Biochemical and physiological effects of chlordimeform. Environ Health Perspect. 1976 Apr;14:71-82. PubMed PMID: 976227; PubMed Central PMCID: PMC1475090.
16: Fleming WJ, Heinz GH, Schuler CA. Lethal and behavioral effects of chlordimeform in bobwhite. Toxicology. 1985 Jul;36(1):37-47. PubMed PMID: 4024127.
17: Ahmed MA, Matsumura F. Synergistic actions of formamidine insecticides on the activity of pyrethroids and neonicotinoids against Aedes aegypti (Diptera: Culicidae). J Med Entomol. 2012 Nov;49(6):1405-10. PubMed PMID: 23270169.
18: Holsapple MP, Yim GK. Decreased gastrointestinal ulcerogenicity of chlordimeform, a basic anti-inflammatory agent. Toxicol Appl Pharmacol. 1981 Jun 15;59(1):107-10. PubMed PMID: 7256749.
19: Wachendörfer G, Valder WA, Kaiser E, Maul V, Wissen W, Ruttner F, Harlander P, Becker W, Bottin F. [Results with acaricide K 79 (chlordimeform hydrochloride) in Messen against honeybee varroatosis]. Dtsch Tierarztl Wochenschr. 1981 May 5;88(5):161-8. German. PubMed PMID: 7016494.
20: Dougan DF, Wade DN. Octopamine receptors in the molluscan aortic bulb: effects of clozapine and chlordimeform. Comp Biochem Physiol C. 1985;82(1):193-7. PubMed PMID: 2865061.
