BRD9876
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H561771

CAS#: 32703-82-5

Description: BRD9876 is a selective inhibitor of MM1S growth. It is selective for microtubule bound Eg5 and causes a rapid arrest in G2/M phase.

Chemical Structure

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BRD9876
CAS# 32703-82-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H561771
Name: BRD9876
CAS#: 32703-82-5
Chemical Formula: C16H14N2
Exact Mass: 234.12
Molecular Weight: 234.300
Elemental Analysis: C, 82.02; H, 6.02; N, 11.96

Price and Availability

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1g USD 220
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Synonym: BRD9876; BRD-9876; BRD 9876;

IUPAC/Chemical Name: 6-(tert-Butyl)naphthalene-2,3-dicarbonitrile

InChi Key: MKILROQBJOOZKC-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14N2/c1-16(2,3)15-5-4-11-6-13(9-17)14(10-18)7-12(11)8-15/h4-8H,1-3H3

SMILES Code: N#CC1=C(C#N)C=C2C=C(C(C)(C)C)C=CC2=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 234.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chen GY, Kang YJ, Gayek AS, Youyen W, Tüzel E, Ohi R, Hancock WO. Eg5 Inhibitors Have Contrasting Effects on Microtubule Stability and Metaphase Spindle Integrity. ACS Chem Biol. 2017 Apr 21;12(4):1038-1046. doi: 10.1021/acschembio.6b01040. Epub 2017 Feb 22. PubMed PMID: 28165699; PubMed Central PMCID: PMC5515541.

2: Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, Hideshima T, Dančík V, Majireck MM, Hussain MM, Singh S, Quiroz R, Iaconelli J, Karmacharya R, Tolliday NJ, Clemons PA, Moore MA, Stern AM, Shamji AF, Ebert BL, Golub TR, Raje NS, Scadden DT, Schreiber SL. Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00030-3. doi: 10.1016/j.celrep.2015.01.017. [Epub ahead of print] PubMed PMID: 25660025; PubMed Central PMCID: PMC4524791.