Byakangelicin

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H584193

CAS#: 482-25-7

Description: Byakangelicin is an inhibitor of aldose reductase and can be helpful in treatment of diabetic cataract.

Chemical Structure

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Byakangelicin
CAS# 482-25-7
Instruction

Theoretical Analysis

Hodoodo Cat#: H584193
Name: Byakangelicin
CAS#: 482-25-7
Chemical Formula: C17H18O7
Exact Mass: 334.11
Molecular Weight: 334.324
Elemental Analysis: C, 61.07; H, 5.43; O, 33.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Biacangelicin; Bjacangelicin; Bjakangelicin; Byak-angelicin; Byakangelicin; Byankagelicine

IUPAC/Chemical Name: 7H-Furo(3,2-g)(1)benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-, (R)-

InChi Key: PKRPFNXROFUNDE-LLVKDONJSA-N

InChi Code: InChI=1S/C17H18O7/c1-17(2,20)11(18)8-23-16-14-10(6-7-22-14)13(21-3)9-4-5-12(19)24-15(9)16/h4-7,11,18,20H,8H2,1-3H3/t11-/m1/s1

SMILES Code: O=C1C=CC2=C(OC)C3=C(OC=C3)C(OC[C@@H](O)C(C)(O)C)=C2O1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 334.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pakrashi A. Endocrinological studies on plant products. 8. Inhibitory effect of byakangelicin on and presence of sulphydryl group in pregnant mare's serum gonadotropin. Indian J Exp Biol. 1968 Oct;6(4):212-5. PubMed PMID: 5720677.

2: Deng GG, Gui ZJ, Yang XW. [Chemical constituents from polarity part in roots of Angelica dahurica var. formosana cv. Chuanbaizhi]. Zhongguo Zhong Yao Za Zhi. 2015 Oct;40(19):3805-10. Chinese. PubMed PMID: 26975106.

3: Pakrashi A. Effect of byakangelicin on placental gonadotropins. Indian J Exp Biol. 1967 Jul;5(3):167-8. PubMed PMID: 5583083.

4: Pakrashi A. Endocrinological studies on plant products: V. Effect of byakangelicin on female sex hormones & on fertility of rats. Indian J Exp Biol. 1967 Apr;5(2):75-9. PubMed PMID: 6070428.

5: Pakrashi A. Endocrinological studies on plant products: VII. Further evidences on the presence of sulphydryl group in human chorionic gonadotropin and mechanism of action of byakangelicin. Indian J Exp Biol. 1968 Oct;6(4):204-11. PubMed PMID: 5720676.

6: Zhao AH, Yang XB, Yang XW, Zhang YB, Xu W, Liu JX. Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells. J Asian Nat Prod Res. 2012;14(10):956-65. doi: 10.1080/10286020.2012.729506. PubMed PMID: 23046467.

7: Song PP, Lv Y, Xu ZL, Wang Q, Wang NH. [Chemical constituents of Angelica nitida roots]. Zhong Yao Cai. 2014 Jan;37(1):55-7. Chinese. PubMed PMID: 25090703.

8: Ding XF, Feng X, Dong YF, Zhao XZ, Chen Y, Wang M. [Studies on chemical constituents of the roots of Angelica pubescens]. Zhong Yao Cai. 2008 Apr;31(4):516-8. Chinese. PubMed PMID: 18661821.

9: Tao Y, Xu H, Wang S, Wang B, Zhang Y, Wang W, Huang B, Wu H, Li D, Zhang Y, Xiao X, Li Y, Yang H, Huang L. Identification of the absorbed constituents after oral administration of Yuanhu Zhitong prescription extract and its pharmacokinetic study by rapid resolution liquid chromatography/quadrupole time-of-flight. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 15;935:1-9. doi: 10.1016/j.jchromb.2013.07.015. Epub 2013 Jul 25. PubMed PMID: 23933613.

10: Kwon OS, Song YS, Shin KH, Ryu JC. Identification of new urinary metabolites of byakangelicin, a component of Angelicae dahuricae Radix, in rats. Arch Pharm Res. 2003 Aug;26(8):606-11. PubMed PMID: 12967195.

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13: Ban HS, Lim SS, Suzuki K, Jung SH, Lee S, Lee YS, Shin KH, Ohuchi K. Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahurica on prostaglandin E2 production. Planta Med. 2003 May;69(5):408-12. PubMed PMID: 12802720.

14: Deng GG, Yang XW, Zhang YB, Xu W, Wei W, Chen TL. [Chemical constituents from lipophilic parts in roots of Angelica dahurica var. formosana cv. Chuanbaizhi]. Zhongguo Zhong Yao Za Zhi. 2015 Jun;40(11):2148-56. Chinese. PubMed PMID: 26552172.

15: Shin KH, Lim SS, Kim DK. Effect of byakangelicin, an aldose reductase inhibitor, on galactosemic cataracts, the polyol contents and Na(+), K(+)ATPase activity in sciatic nerves of strepto-zotocin-induced diabetic rats. Phytomedicine. 1998 Apr;5(2):121-7. doi: 10.1016/S0944-7113(98)80008-1. PubMed PMID: 23195764.

16: Chen Q, Li P, He J, Zhang Z, Liu J. Supercritical fluid extraction for identification and determination of volatile metabolites from Angelica dahurica by GC-MS. J Sep Sci. 2008 Oct;31(18):3218-24. doi: 10.1002/jssc.200800325. PubMed PMID: 18705001.

17: Zhao A, Yang X, Yang X, Liu J, Wang Q, Wang W. [A new natural product from root of Angelica dahurica cv. Qibaizhi]. Zhongguo Zhong Yao Za Zhi. 2012 Aug;37(16):2400-7. Chinese. PubMed PMID: 23234138.

18: Yuan ZM, Wang J, Jia TZ, Chen JF. [Determination of four coumarin constituents before and after Angelicae Dahuricae Radix stewed with yellow rice wine and research on its mutual transformation mechanism]. Zhongguo Zhong Yao Za Zhi. 2016 Aug;41(16):3032-3035. doi: 10.4268/cjcmm20161615. Chinese. PubMed PMID: 28920344.

19: Shi Y, Lei Y, Xu HY, Zhang Y, Li DF, Liu F, Yang HJ. [Quantitative determination of three active ingredients for quality evaluation of Angelica dahurica]. Zhongguo Zhong Yao Za Zhi. 2015 Mar;40(5):915-9. Chinese. PubMed PMID: 26087556.

20: Huang P, Zheng XZ, Lai MX, Rao WY, Nishi M, Nakanishi T. [Studies on chemical constituents of Peucedanum medium Dunn var. garcile Dunn ex Shan at Sheh]. Zhongguo Zhong Yao Za Zhi. 2000 Apr;25(4):222-4. Chinese. PubMed PMID: 12512437.