WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561796
CAS#: 1204329-34-9
Description: BI-9627 is a highly potent NHE1 inhibitor with low DDI potential, excellent pharmacokinetics, and good selectivity against NHE2 and NHE3.
Hodoodo Cat#: H561796
Name: BI-9627
CAS#: 1204329-34-9
Chemical Formula: C16H19F3N4O2
Exact Mass: 356.15
Molecular Weight: 356.340
Elemental Analysis: C, 53.93; H, 5.37; F, 15.99; N, 15.72; O, 8.98
Synonym: BI-9627; BI 9627; BI9627;
IUPAC/Chemical Name: 4-(1-Acetylpiperidin-4-yl)-N-carbamimidoyl-3-(trifluoromethyl)benzamide
InChi Key: QMHRLXNEGYTSRV-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H19F3N4O2/c1-9(24)23-6-4-10(5-7-23)12-3-2-11(14(25)22-15(20)21)8-13(12)16(17,18)19/h2-3,8,10H,4-7H2,1H3,(H4,20,21,22,25)
SMILES Code: O=C(NC(N)=N)C1=CC=C(C2CCN(C(C)=O)CC2)C(C(F)(F)F)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMF | 10.0 | 28.06 | |
DMSO | 60.0 | 168.38 | |
DMSO:PBS (pH 7.2) (1:7) | 0.1 | 0.34 |
The following data is based on the product molecular weight 356.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |