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Paracetamol
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H581053

CAS#: 103-90-2

Description: Paracetamol is also known as Acetaminophen. Paracetamol is Widely used analgesic and antipyretic agent for mild-to-moderate pain and fever. it is a selective cyclooxygenase-2 inhibitor. Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.

Chemical Structure

Paracetamol

CAS# 103-90-2

Instruction

Theoretical Analysis

Hodoodo Cat#: H581053
Name: Paracetamol
CAS#: 103-90-2
Chemical Formula: C8H9NO2
Exact Mass: 151.06
Molecular Weight: 151.170
Elemental Analysis: C, 63.56; H, 6.00; N, 9.27; O, 21.17

Price and Availability

Size	Price	Availability
1g	USD 90	Ready to ship
5g	USD 150	Ready to ship
500g	USD 310	2 Weeks
25g	USD 400	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Paracetamol; p-Hydroxyacetanilide; Acetaminophen; N-Acetyl-4-aminophenol; APAP; N-(4-hydroxyphenyl)acetamide.

IUPAC/Chemical Name: Acetaminophen; 4-Acetamidophenol; Tylenol; N-(4-Hydroxyphenyl)acetamide

InChi Key: RZVAJINKPMORJF-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

SMILES Code: O=C(C)NC1=CC=C(O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 151.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ibáñez-Redín G, Wilson D, Gonçalves D, Oliveira ON Jr.. Low-cost screen-printed electrodes based on electrochemically reduced graphene oxide-carbon black nanocomposites for dopamine, epinephrine and paracetamol detection. J Colloid Interface Sci. 2017 Dec 30;515:101-108. doi: 10.1016/j.jcis.2017.12.085. [Epub ahead of print] PubMed PMID: 29331776.

2: Saeedan AS, Singh I, Ansari MN, Singh M, Rawat JK, Devi U, Gautam S, Yadav RK, Kaithwas G. Effect of early natal supplementation of paracetamol on attenuation of exotoxin/endotoxin induced pyrexia and precipitation of autistic like features in albino rats. Inflammopharmacology. 2018 Jan 11. doi: 10.1007/s10787-017-0440-2. [Epub ahead of print] PubMed PMID: 29327281.

3: Kumar RD, Premnath U. Novel Regimens in the Treatment of Paracetamol (Acetaminophen) Poisoning. J Assoc Physicians India. 2017 Nov;65(11):71-78. PubMed PMID: 29322714.

4: Morthorst BR, Erlangsen A, Nordentoft M, Hawton K, Hoegberg LCG, Dalhoff KP. Availability of Paracetamol Sold Over-the-Counter in Europe: A Descriptive Cross-Sectional International Survey of Pack Size Restriction. Basic Clin Pharmacol Toxicol. 2018 Jan 10. doi: 10.1111/bcpt.12959. [Epub ahead of print] PubMed PMID: 29319222.

5: Esh CJ, Mauger AR, Palfreeman RA, Al-Janubi H, Taylor L. Acetaminophen (Paracetamol): Use beyond Pain Management and Dose Variability. Front Physiol. 2017 Dec 22;8:1092. doi: 10.3389/fphys.2017.01092. eCollection 2017. PubMed PMID: 29312002; PubMed Central PMCID: PMC5744234.

6: Sharma R, Gupta R, Choudhary R, Singh Bajwa SJ. Postoperative Analgesia with Intravenous Paracetamol and Dexmedetomidine in Laparoscopic Cholecystectomy Surgeries: A Prospective Randomized Comparative Study. Int J Appl Basic Med Res. 2017 Oct-Dec;7(4):218-222. doi: 10.4103/ijabmr.IJABMR_25_17. PubMed PMID: 29308357; PubMed Central PMCID: PMC5752804.

7: Sehitoglu MH, Yayla M, Kiraz A, Oztopuz RO, Bayir Y, Karaca T, Khalid S, Akpinar E. The effects of apomorphine on paracetamol-induced hepatotoxicity in rats. Cell Mol Biol (Noisy-le-grand). 2017 Dec 30;63(12):40-44. doi: 10.14715/cmb/2017.63.12.10. PubMed PMID: 29307340.

8: Arendrup FS, Mazaud-Guittot S, Jégou B, Kristensen DM. EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development? Endocr Connect. 2018 Jan 5. pii: EC-17-0298. doi: 10.1530/EC-17-0298. [Epub ahead of print] PubMed PMID: 29305399.

9: Salvatore S, Domanska D, Wood M, Nordeng H, Sandve GK. Complex patterns of concomitant medication use: A study among Norwegian women using paracetamol during pregnancy. PLoS One. 2017 Dec 28;12(12):e0190101. doi: 10.1371/journal.pone.0190101. eCollection 2017. PubMed PMID: 29284043; PubMed Central PMCID: PMC5746239.

10: Heydari SM, Hashemi SJ, Pourali S. The Comparison of Preventive Analgesic Effects of Ketamine, Paracetamol and Magnesium Sulfate on Postoperative Pain Control in Patients Undergoing Lower Limb Surgery: A Randomized Clinical Trial. Adv Biomed Res. 2017 Oct 25;6:134. doi: 10.4103/2277-9175.217217. eCollection 2017. PubMed PMID: 29279832; PubMed Central PMCID: PMC5674649.

11: Taipale-Kovalainen K, Karttunen AP, Ketolainen J, Korhonen O. Lubricant based determination of design space for continuously manufactured high dose paracetamol tablets. Eur J Pharm Sci. 2017 Dec 24;115:1-10. doi: 10.1016/j.ejps.2017.12.021. [Epub ahead of print] PubMed PMID: 29277668.

12: Matsumura S, Oshima A, Fujinuma S, Tanaka K, Nagano N, Miyake F, Masutani S, Tamura M, Ueda K, Namba F. Low-Dose Intravenous Paracetamol for Patent Ductus Arteriosus in Indomethacin-Resistant or Contraindicated Preterm Infants: Three Cases Reports. AJP Rep. 2017 Oct;7(4):e230-e233. doi: 10.1055/s-0037-1615260. Epub 2017 Dec 21. PubMed PMID: 29276647; PubMed Central PMCID: PMC5740229.

13: Queirós C, Salvador P, Ventura A, Lopes D. Methemoglobinemia After Paracetamol Ingestion: A Case Report. Acta Med Port. 2017 Oct 31;30(10):753-756. doi: 10.20344/amp.8722. Epub 2017 Oct 31. PubMed PMID: 29268071.

14: Furyk J, Levas D, Close B, Laspina K, Fitzpatrick M, Robinson K, Vangaveti VN, Ray R. Intravenous versus oral paracetamol for acute pain in adults in the emergency department setting: a prospective, double-blind, double-dummy, randomised controlled trial. Emerg Med J. 2017 Dec 15. pii: emermed-2017-206787. doi: 10.1136/emermed-2017-206787. [Epub ahead of print] PubMed PMID: 29247042.

15: Reed K, Collaku A, Moreira S. Efficacy and safety of twice daily sustained-release paracetamol formulation for osteoarthritis pain of the knee or hip: a randomized, double-blind, placebo-controlled, twelve-week study. Curr Med Res Opin. 2018 Jan 11:1-11. doi: 10.1080/03007995.2017.1417245. [Epub ahead of print] PubMed PMID: 29239664.

16: Al-Lawama M, Alammori I, Abdelghani T, Badran E. Oral paracetamol versus oral ibuprofen for treatment of patent ductus arteriosus. J Int Med Res. 2017 Jan 1:300060517722698. doi: 10.1177/0300060517722698. [Epub ahead of print] PubMed PMID: 29239259.

17: Sharma CV, Long JH, Shah S, Rahman J, Perrett D, Ayoub SS, Mehta V. First evidence of the conversion of paracetamol to AM404 in human cerebrospinal fluid. J Pain Res. 2017 Nov 28;10:2703-2709. doi: 10.2147/JPR.S143500. eCollection 2017. PubMed PMID: 29238213; PubMed Central PMCID: PMC5716395.

18: Saliba SW, Marcotegui AR, Fortwängler E, Ditrich J, Perazzo JC, Muñoz E, de Oliveira ACP, Fiebich BL. AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity. J Neuroinflammation. 2017 Dec 13;14(1):246. doi: 10.1186/s12974-017-1014-3. PubMed PMID: 29237478; PubMed Central PMCID: PMC5729401.

19: Belal F, Omar MA, Derayea S, Hammad MA, Zayed S, Saleh SF. Simultaneous Determination of Tizanidine, Nimesulide, Aceclofenac and Paracetamol in Tablets and Biological Fluids Using Micellar Liquid Chromatography. J Chromatogr Sci. 2017 Dec 11. doi: 10.1093/chromsci/bmx105. [Epub ahead of print] PubMed PMID: 29236980.

20: McNulty R, Lim JME, Chandru P, Gunja N. Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose. Clin Toxicol (Phila). 2017 Dec 8:1-4. doi: 10.1080/15563650.2017.1408812. [Epub ahead of print] PubMed PMID: 29219630.

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Paracetamol featured