WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584242
CAS#: 119068-46-1
Description: BO 1341 is a semisynthetic cephalosporin having a 6,7-dihydroxyisoquinoline moiety at the C-3 methylene carbon.
Hodoodo Cat#: H584242
Name: BO 1341
CAS#: 119068-46-1
Chemical Formula: C26H24N6O9S2
Exact Mass: 628.10
Molecular Weight: 628.631
Elemental Analysis: C, 49.68; H, 3.85; N, 13.37; O, 22.91; S, 10.20
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Synonym: BO 1341; BO1341; BO-1341
IUPAC/Chemical Name: Isoquinolinium, 2-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydroxy-, hydroxide, inner salt, (6R-trans)-
InChi Key: XMOLQYFYIRKUAY-PLEZTBHSSA-N
InChi Code: InChI=1S/C26H24N6O9S2/c1-26(2,24(39)40)41-30-17(14-10-43-25(27)28-14)20(35)29-18-21(36)32-19(23(37)38)13(9-42-22(18)32)8-31-4-3-11-5-15(33)16(34)6-12(11)7-31/h3-7,10,18,22H,8-9H2,1-2H3,(H6,27,28,29,34,35,37,38,39,40)/b30-17+/t18-,22-/m1/s1
SMILES Code: OC1=CC2=C[N+](CC(CS[C@]3([H])[C@@H]4NC(/C(C5=CSC(N)=N5)=N/OC(C)(C(O)=O)C)=O)=C(C([O-])=O)N3C4=O)=CC=C2C=C1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 628.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Hazumi N, Matsuda K, Sanada M, Ohtake N, Tanaka N. Resistance to a new catecholic cephem, BO-1341, in Pseudomonas aeruginosa PAO. J Antimicrob Chemother. 1992 Mar;29(3):287-97. PubMed PMID: 1592698.
2: Nakagawa S, Sanada M, Matsuda K, Hashizume T, Asahi Y, Ushijima R, Ohtake N, Tanaka N. In vitro and in vivo antibacterial activities of BO-1341, a new antipseudomonal cephalosporin. Antimicrob Agents Chemother. 1989 Sep;33(9):1423-7. PubMed PMID: 2510590; PubMed Central PMCID: PMC172677.
3: Sanada M, Hashizume T, Matsuda K, Nakagawa S, Tanaka N. Mode of action of BO-1341: transport pathway through the outer membrane of Escherichia coli. Drugs Exp Clin Res. 1988;14(6):397-402. PubMed PMID: 3063475.
4: Hashizume T, Sanada M, Nakagawa S, Tanaka N. Comparison of transport pathways of catechol-substituted cephalosporins, BO-1236 and BO-1341, through the outer membrane of Escherichia coli. J Antibiot (Tokyo). 1990 Dec;43(12):1617-20. PubMed PMID: 2276982.