WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584251
CAS#: 95648-98-9
Description: Bombolitin V is a mast cell degranulating peptide from the venom of the bumblebee Megabombus pennsylvanicus.
Hodoodo Cat#: H584251
Name: Bombolitin V
CAS#: 95648-98-9
Chemical Formula: C81H144N22O19
Exact Mass: 1,729.10
Molecular Weight: 1,730.178
Elemental Analysis: C, 56.23; H, 8.39; N, 17.81; O, 17.57
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Synonym: Bombolitin V
IUPAC/Chemical Name: L-Leucinamide, L-isoleucyl-L-asparaginyl-L-valyl-L-leucylglycyl-L-isoleucyl-L-leucylglycyl-L-leucyl-L-leucylglycyl-L-lysyl-L-alanyl-L-leucyl-L-seryl-L-histidyl-
InChi Key: IOCWBJCCGSYJPN-SDXYAQEHSA-N
InChi Code: InChI=1S/C81H144N22O19/c1-20-47(17)65(84)79(120)98-59(33-61(83)105)77(118)103-66(46(15)16)80(121)99-54(28-42(7)8)71(112)89-37-64(108)102-67(48(18)21-2)81(122)100-55(29-43(9)10)72(113)88-36-63(107)93-56(30-44(11)12)74(115)96-53(27-41(5)6)70(111)87-35-62(106)92-51(24-22-23-25-82)73(114)91-49(19)69(110)95-57(31-45(13)14)75(116)101-60(38-104)78(119)97-58(32-50-34-86-39-90-50)76(117)94-52(68(85)109)26-40(3)4/h34,39-49,51-60,65-67,104H,20-33,35-38,82,84H2,1-19H3,(H2,83,105)(H2,85,109)(H,86,90)(H,87,111)(H,88,113)(H,89,112)(H,91,114)(H,92,106)(H,93,107)(H,94,117)(H,95,110)(H,96,115)(H,97,119)(H,98,120)(H,99,121)(H,100,122)(H,101,116)(H,102,108)(H,103,118)/t47-,48-,49-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,65-,66-,67-/m0/s1
SMILES Code: CC(C)C[C@@H](C(N)=O)NC([C@H](CC1=CNC=N1)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CNC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC(CNC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)CC)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 1,730.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Argiolas A, Pisano JJ. Bombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus. J Biol Chem. 1985 Feb 10;260(3):1437-44. PubMed PMID: 2578459.
2: Ahmad A, Ranjan S, Zhang W, Zou J, Pyykkö I, Kinnunen PK. Novel endosomolytic peptides for enhancing gene delivery in nanoparticles. Biochim Biophys Acta. 2015 Feb;1848(2):544-53. doi: 10.1016/j.bbamem.2014.11.008. Epub 2014 Nov 15. PubMed PMID: 25445677.
3: Schievano E, Mammi S, Monticelli L, Ciardella M, Peggion E. Conformational studies of a bombolitin III-derived peptide mimicking the four-helix bundle structural motif of proteins. J Am Chem Soc. 2003 Dec 17;125(50):15314-23. PubMed PMID: 14664575.
4: Dohtsu K, Okumura K, Hagiwara K, Palma MS, Nakajima T. Isolation and sequence analysis of peptides from the venom of Protonectarina sylveirae (Hymenoptera-Vespidae). Nat Toxins. 1993;1(5):271-6. PubMed PMID: 7513243.
