WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584315
CAS#: 98410-36-7
Description: Palatrigine, also known as BW A256C, is a chemically novel agent which exhibits in a single molecule both angiotensin converting enzyme (ACE) inhibition and beta-adrenoceptor-blocking properties.
Hodoodo Cat#: H584315
Name: Palatrigine
CAS#: 98410-36-7
Chemical Formula: C12H13Cl2N5
Exact Mass: 297.05
Molecular Weight: 298.171
Elemental Analysis: C, 48.34; H, 4.39; Cl, 23.78; N, 23.49
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Synonym: Palatrigine ; BW A256C; BW-A 256C
IUPAC/Chemical Name: 1,2,4-Triazin-3-amine, 2,5-dihydro-6-(2,3-dichlorophenyl)-5-imino-2-(1-methylethyl)-
InChi Key: XJQJAFGEQVKYNF-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H13Cl2N5/c1-6(2)19-12(16)17-11(15)10(18-19)7-4-3-5-8(13)9(7)14/h3-6H,1-2H3,(H3,15,16,17)
SMILES Code: NC(N(C(C)C)N=C1C2=CC=CC(Cl)=C2Cl)=NC1=N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 298.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Allan G, Donoghue S, Follenfant MJ, Sawyer DA. BW A256C, a chemically novel class 1 antiarrhythmic agent. A comparison of in vitro and in vivo activity with other class 1 antiarrhythmic agents. Br J Pharmacol. 1986 Jun;88(2):333-43. PubMed PMID: 3730698; PubMed Central PMCID: PMC1916834.
2: Donoghue S, Payne PN, Allan G. Effects of BW A256C, a novel class 1 antiarrhythmic agent, on maximum rate of depolarisation of cardiac action potentials in vitro: frequency, use, and voltage dependence. J Cardiovasc Pharmacol. 1987 Jan;9(1):12-8. PubMed PMID: 2434786.
3: Allan G, Cambridge D, Hardy GW, Follenfant MJ. BW A575C, a chemically novel agent with angiotensin converting enzyme inhibitor and beta-adrenoceptor-blocking properties. Br J Pharmacol. 1987 Mar;90(3):609-15. PubMed PMID: 2882805; PubMed Central PMCID: PMC1917187.
