1V209
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Hodoodo CAT#: H527786

CAS#: 1062444-54-5

Description: 1V209, also known as TLR7 agonist T7, is a novel Toll-like receptor 7 (TLR7) agonist, eliciting the nonspecific antitumor responses and strengthening the specific humoral and cellular immune responses.

Chemical Structure

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1V209
CAS# 1062444-54-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H527786
Name: 1V209
CAS#: 1062444-54-5
Chemical Formula: C16H17N5O5
Exact Mass: 359.12
Molecular Weight: 359.342
Elemental Analysis: C, 53.48; H, 4.77; N, 19.49; O, 22.26

Price and Availability

Size Price Availability Quantity
50mg USD 1150 2 Weeks
100mg USD 1950 2 Weeks
200mg USD 3450 2 Weeks
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Related CAS #: 1062444-54-5,  

Synonym: TLR7 agonist T7; 1V209; 1V-209; 1V 209;

IUPAC/Chemical Name: 4-[[6-Amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]-benzoic acid

InChi Key: ATISKRYGYNSRNP-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H17N5O5/c1-25-6-7-26-15-19-12(17)11-13(20-15)21(16(24)18-11)8-9-2-4-10(5-3-9)14(22)23/h2-5H,6-8H2,1H3,(H,18,24)(H,22,23)(H2,17,19,20)

SMILES Code: O=C(O)C1=CC=C(CN2C(NC3=C(N)N=C(OCCOC)N=C23)=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 359.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhang N, Jin G, Jin Z, Liu B, Peng B, Gao N, Hu Y, Tang L. [Combination of TLR7 agonist T7-ethacrynic acid conjugate with ROR1 has a stronger anti-breast cancer effect]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Jul;32(7):876-80. Chinese. PubMed PMID: 27363264.

2: Wang XD, Gao NN, Diao YW, Liu Y, Gao D, Li W, Wan YY, Zhong JJ, Jin GY. Conjugation of toll-like receptor-7 agonist to gastric cancer antigen MG7-Ag exerts antitumor effects. World J Gastroenterol. 2015 Jul 14;21(26):8052-60. doi: 10.3748/wjg.v21.i26.8052. PubMed PMID: 26185376; PubMed Central PMCID: PMC4499347.

3: Lin G, Wang X, Yi W, Zhang C, Xu G, Zhu X, Cai Z, Liu Y, Diao Y, Lin MC, Jin G. A conjugate of octamer-binding transcription factor 4 and toll-like receptor 7 agonist prevents the growth and metastasis of testis embryonic carcinoma. J Transl Med. 2015 May 20;13:166. doi: 10.1186/s12967-015-0524-y. PubMed PMID: 25990580; PubMed Central PMCID: PMC4455914.