WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H581154
CAS#: 1448-16-4
Description: Bis(diazoacetyl)butane is also known as DAB (1,4-bisdiazoacetyl butane), it is a mutagen and traditionally related to radio-mimetic chemical mutagens due to the similarity of appearance of mutagenic action of this mutagen and physical mutagens such as gamma and x-rays. Bis(diazoacetyl)butane has anti-tumor and carcinogenic activity.
Hodoodo Cat#: H581154
Name: Bis(diazoacetyl)butane
CAS#: 1448-16-4
Chemical Formula: C6H8N4O
Exact Mass: 152.07
Molecular Weight: 152.160
Elemental Analysis: C, 47.36; H, 5.30; N, 36.82; O, 10.51
This product is not in stock, which may be available by custom synthesis.
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Synonym: Bis(diazoacetyl)butane; DAB (mutagen); Supermutagen; 1,4-Bis(diazoacetyl)butane; 1,4-Bis-diazoacetylbutane;
IUPAC/Chemical Name: 1,4-Bis-diazoacetylbutane
InChi Key: IPWXWJXIGXOPQP-UHFFFAOYSA-N
InChi Code: InChI=1S/C6H8N4O/c1-5(11)6(10-8)3-2-4-9-7/h4H,2-3H2,1H3
SMILES Code: [N-]=[N+]=CCCC(C(C)=O)=[N+]=[N-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 152.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Aslanian MM, Kim AI, Smirnova VA. [Characteristics of the mutagenic action of 1,4-bis-diazoacetylbutane on mature Drosophila melanogaster sperm]. Genetika. 1981;17(4):677-83. Russian. PubMed PMID: 6785154.
2: Shigaeva MKh, Akhmatullina NB, Dzhangalina NK. [Effect of nonmutagenic doses of 1,4-bis-diazoacetylbutane on Streptomyces griseus]. Mikrobiologiia. 1982 Nov-Dec;51(6):993-6. Russian. PubMed PMID: 6818438.
3: Ivanovskiĭ IuA, Kulinich NM. [Stimulating action of gamma irradiation and alkylating compounds on the brine shrimp, Artemia salina. 3. 3H-thymidine and 3H-uridine incorporation into the nauplii of A. salina irradiated or treated with 1-4-bis-diazoacetylbutane at the embryonic diapause stage]. Radiobiologiia. 1980 May-Jun;20(3):414-8. Russian. PubMed PMID: 7406993.
4: Gorbunova NA, Sukharevich ME, Iakovleva EP. [Natural and induced variability of pathogen, producing antifungal antibiotic, imbrimycin]. Antibiot Khimioter. 1998;43(3):3-7. Russian. PubMed PMID: 9606489.
5: Ivanovskiĭ IuA. [Stimulating effect of gamma-irradiation and alkylating compounds on the branchiopod crustacean Artemia salina. 2. Effect of gamma-radiation and chemical mutagens on the growth of A. salina]. Radiobiologiia. 1980 Mar-Apr;20(2):303-6. Russian. PubMed PMID: 7406992.
