WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562367
CAS#: 844882-93-5
Description: IFN-alpha, also known as IFNAR-IN-1 or IFN-alpha/IFNAR-IN-1, is a nonpeptidic inhibitor of IFN-alpha and IFNAR interaction.
Hodoodo Cat#: H562367
Name: IFN-alpha
CAS#: 844882-93-5
Chemical Formula: C18H17NS
Exact Mass: 279.11
Molecular Weight: 279.400
Elemental Analysis: C, 77.38; H, 6.13; N, 5.01; S, 11.47
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: IFN-alpha; IFN alpha; IFNAR-IN-1; IFNAR IN 1; IFNARIN1; IFNAR inhibitor 1; IFNAR-inhibitor-1; IFN-alpha and IFNAR interaction inhibitor;
IUPAC/Chemical Name: Methyl-[2-(naphthalen-1-ylsulfanyl)-benzyl]-amine
InChi Key: OHDXDNUPVVYWOV-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H17NS/c1-19-13-15-8-3-5-11-17(15)20-18-12-6-9-14-7-2-4-10-16(14)18/h2-12,19H,13H2,1H3
SMILES Code: CNCC1=CC=CC=C1SC2=C3C=CC=CC3=CC=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 279.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Aloia AL, Calvert JK, Clarke JN, Davies LT, Helbig KJ, Pitson SM, Carr JM. Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection. Clin Transl Immunology. 2017 Jul 21;6(7):e151. doi: 10.1038/cti.2017.32. eCollection 2017 Jul. PubMed PMID: 28791126; PubMed Central PMCID: PMC5539417.
2: Zhao LJ, He SF, Liu Y, Zhao P, Bian ZQ, Qi ZT. Inhibition of STAT Pathway Impairs Anti-Hepatitis C Virus Effect of Interferon Alpha. Cell Physiol Biochem. 2016;40(1-2):77-90. Epub 2016 Nov 18. PubMed PMID: 27855377.
3: Qashqari H, Al-Mars A, Chaudhary A, Abuzenadah A, Damanhouri G, Alqahtani M, Mahmoud M, El Sayed Zaki M, Fatima K, Qadri I. Understanding the molecular mechanism(s) of hepatitis C virus (HCV) induced interferon resistance. Infect Genet Evol. 2013 Oct;19:113-9. doi: 10.1016/j.meegid.2013.06.025. Epub 2013 Jul 5. Review. PubMed PMID: 23831932.
4: Tsuno T, Mejido J, Zhao T, Phillips T, Myers TG, Bekisz J, Zoon KC. BID is a critical factor controlling cell viability regulated by IFN-α. J Immunother. 2012 Jan;35(1):23-31. doi: 10.1097/CJI.0b013e3182372dcf. PubMed PMID: 22130162; PubMed Central PMCID: PMC3241910.
5: Vitale G, de Herder WW, van Koetsveld PM, Waaijers M, Schoordijk W, Croze E, Colao A, Lamberts SW, Hofland LJ. IFN-beta is a highly potent inhibitor of gastroenteropancreatic neuroendocrine tumor cell growth in vitro. Cancer Res. 2006 Jan 1;66(1):554-62. PubMed PMID: 16397272.
6: Manca C, Tsenova L, Freeman S, Barczak AK, Tovey M, Murray PJ, Barry C, Kaplan G. Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway. J Interferon Cytokine Res. 2005 Nov;25(11):694-701. PubMed PMID: 16318583.
7: Takauji R, Iho S, Takatsuka H, Yamamoto S, Takahashi T, Kitagawa H, Iwasaki H, Iida R, Yokochi T, Matsuki T. CpG-DNA-induced IFN-alpha production involves p38 MAPK-dependent STAT1 phosphorylation in human plasmacytoid dendritic cell precursors. J Leukoc Biol. 2002 Nov;72(5):1011-9. PubMed PMID: 12429724.
8: Yang CH, Shi W, Basu L, Murti A, Constantinescu SN, Blatt L, Croze E, Mullersman JE, Pfeffer LM. Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor. J Biol Chem. 1996 Apr 5;271(14):8057-61. PubMed PMID: 8626489.
