7,8-Dihydroxyflavone
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H562386

CAS#: 38183-03-8

Description: 7,8-Dihydroxyflavone is an agonist of tyrosine receptor kinase B (TrkB). It acts by promoting immature neuron survival after TBI through activation of the BDNF signaling pathway.

Chemical Structure

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7,8-Dihydroxyflavone
CAS# 38183-03-8
Instruction

Theoretical Analysis

Hodoodo Cat#: H562386
Name: 7,8-Dihydroxyflavone
CAS#: 38183-03-8
Chemical Formula: C15H10O4
Exact Mass: 254.06
Molecular Weight: 0.000
Elemental Analysis: Chemical Formula: C15H10O4 Exact Mass: 254.0579 Molecular Weight: 254.2410 Elemental Analysis: C, 70.86; H, 3.96; O, 25.17

Price and Availability

Size Price Availability Quantity
10mg USD 180
100mg USD 300
250mg USD 550
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Synonym: 7,8-Dihydroxyflavone; DHF; 7,8-DHF;

IUPAC/Chemical Name: 7,8-Dihydroxy-2-phenyl-chromen-4-one

InChi Key: COCYGNDCWFKTMF-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H

SMILES Code: O=C1C=C(C2=CC=CC=C2)OC3=C1C=CC(O)=C3O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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4: Liu C, Chan CB, Ye K. 7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders. Transl Neurodegener. 2016 Jan 6;5:2. doi: 10.1186/s40035-015-0048-7. eCollection 2016. Review. PubMed PMID: 26740873; PubMed Central PMCID: PMC4702337.

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6: Du X, Hill RA. 7,8-Dihydroxyflavone as a pro-neurotrophic treatment for neurodevelopmental disorders. Neurochem Int. 2015 Oct;89:170-80. doi: 10.1016/j.neuint.2015.07.021. Epub 2015 Jul 26. Review. PubMed PMID: 26220903.

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8: Zeng Y, Wang X, Wang Q, Liu S, Hu X, McClintock SM. Small molecules activating TrkB receptor for treating a variety of CNS disorders. CNS Neurol Disord Drug Targets. 2013 Nov;12(7):1066-77. Review. PubMed PMID: 23844685.

9: Obianyo O, Ye K. Novel small molecule activators of the Trk family of receptor tyrosine kinases. Biochim Biophys Acta. 2013 Oct;1834(10):2213-8. doi: 10.1016/j.bbapap.2012.08.021. Epub 2012 Sep 6. Review. PubMed PMID: 22982231; PubMed Central PMCID: PMC3602283.

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