WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H407903
CAS#: 2201057-10-3
Description: MDK-7103 is a MATA2 inhibitor that are useful as therapeutic agents for treating malignancies. MDK-7103 was reported in (US 20180079753 A1 20180322 and WO 2018045071 A1 20180308) MDK-7103 has no formal name. MDK-7103 has CAS#2201057-10-3. For the convenience of scientific communication, we temporally name it as MDK-7103. The last 4 digit of its CAS# was used in its name.
Hodoodo Cat#: H407903
Name: MDK-7103
CAS#: 2201057-10-3
Chemical Formula: C31H22N6OS
Exact Mass: 526.16
Molecular Weight: 526.618
Elemental Analysis: C, 70.70; H, 4.21; N, 15.96; O, 3.04; S, 6.09
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Synonym: MDK-7103; MDK7103; MDK 7103;
IUPAC/Chemical Name: 6-(2-methylbenzo[d]thiazol-6-yl)-2,3-diphenyl-5-(pyridin-2-ylamino)pyrazolo[1,5-a]pyrimidin-7(4H)-one
InChi Key: ZTNQNZDNHUAVEI-UHFFFAOYSA-N
InChi Code: InChI=1S/C31H22N6OS/c1-19-33-23-16-15-22(18-24(23)39-19)27-29(34-25-14-8-9-17-32-25)35-30-26(20-10-4-2-5-11-20)28(36-37(30)31(27)38)21-12-6-3-7-13-21/h2-18,35H,1H3,(H,32,34)
SMILES Code: O=C1C(C2=CC=C3N=C(C)SC3=C2)=C(NC4=NC=CC=C4)NC5=C(C6=CC=CC=C6)C(C7=CC=CC=C7)=NN15
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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| In vitro activity: | |
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The following data is based on the product molecular weight 526.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as inhibitors of cellular metabolic processes and their preparation
By Konteatis, Zenon D.; Sui, Zhihua; Travins, Jeremy M.; Ye, Zhixiong
From U.S. Pat. Appl. Publ. (2018), US 20180079753 A1 20180322. | Language: English, Database: CAPLUS
2. Preparation of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as methionine adenosyltransferase 2A inhibitors for treatment of cancer
By Konteatis, Zenon D.; Sui, Zhihua; Travins, Jeremy M.; Ye, Zhixiong
From PCT Int. Appl. (2018), WO 2018045071 A1 20180308. | Language: English, Database: CAPLUS
