Hns 32

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H584424

CAS#: 186086-10-2

Description: Hns 32 possesses antiarrhythmic properties with vasodilator action in dog and guinea pig hearts.

Chemical Structure

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Hns 32
CAS# 186086-10-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H584424
Name: Hns 32
CAS#: 186086-10-2
Chemical Formula: C26H33N3
Exact Mass: 387.27
Molecular Weight: 387.571
Elemental Analysis: C, 80.58; H, 8.58; N, 10.84

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Hns 32; Hns32; Hns-32

IUPAC/Chemical Name: Azulene-1-carboxamidine, N,N,3,8-tetramethyl-5-(1-methylethyl)-N'-(2-pyridinylmethyl)-dimethyl-

InChi Key: IOMGMLINRUTUCG-BYCLXTJYSA-N

InChi Code: InChI=1S/C26H33N3/c1-16(2)22-13-12-17(3)23-24(20(22)6)18(4)19(5)25(23)26(29(7)8)28-15-21-11-9-10-14-27-21/h9-14,16H,15H2,1-8H3/b28-26+

SMILES Code: CC(C1=CC=C(C)C2=C(/C(N(C)C)=N\CC3=NC=CC=C3)C(C)=C(C)C2=C1C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 387.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Saitoh M, Sugiyama A, Nakazawa T, Hashimoto K. Cardiovascular effects of orally administered HNS-32, an originally synthesized azulene-1-carboxamidine derivative, assessed in the in vivo rat model. Jpn J Pharmacol. 2002 Jul;89(3):316-9. PubMed PMID: 12184739.

2: Tanaka Y, Shigenobu K. A review of HNS-32: a novel azulene-1-carboxamidine derivative with multiple cardiovascular protective actions. Cardiovasc Drug Rev. 2001 Winter;19(4):297-312. Review. PubMed PMID: 11830749.

3: Noguchi K, Kase J, Saitoh M, Masumiya H, Saitoh M, Nakazawa T, Tanaka Y, Tanaka H, Hashimoto K, Shigenobu K. Effects of HNS-32, a novel antiarrhythmic agent, on guinea-pig myocardium. Pharmacology. 2002 Jan;64(1):36-42. PubMed PMID: 11731720.

4: Noguchi K, Saitoh M, Nakazawa T, Tanaka H, Tanaka Y, Shigenobu K. Cerebral artery selective inhibition of protein kinase c-mediated contraction by hns-32, a novel azulene-1-carboxamidine derivative. Res Commun Mol Pathol Pharmacol. 2000;107(1-2):45-54. PubMed PMID: 11334370.

5: Tanaka Y, Mitani A, Igarashi T, Someya S, Otsuka K, Imai T, Yamaki F, Tanaka H, Saitoh M, Nakazawa T, Noguchi K, Hashimoto K, Shigenobu K. HNS-32, a novel azulene-1-carboxamidine derivative, inhibits nifedipine-sensitive and -insensitive contraction of the isolated rabbit aorta. Naunyn Schmiedebergs Arch Pharmacol. 2001 Mar;363(3):344-52. PubMed PMID: 11284450.

6: Saitoh M, Aye NN, Komori S, Nakazawa T, Hashimoto K. Effects of HNS-32, a novel antiarrhythmic drug, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats. Mol Cell Biochem. 2000 Feb;205(1-2):133-40. PubMed PMID: 10821431.

7: Saitoh M, Sugiyama A, Hagihara A, Nakazawa T, Hashimoto K. Cardiovascular and antiarrhythmic effects of the azulene-1-carboxamidine derivative N1,N1-dimethyl-N2-(2-pyridylmethyl)-5-isopropyl-3, 8-dimethylazulene-1-carboxamidine. Arzneimittelforschung. 1997 Jul;47(7):810-5. PubMed PMID: 9272236.