WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562618
CAS#: 128700-97-0
Description: AS-HK014 is a trypanocidal curcumin analog bearing a mono-enone linker motif act on Trypanosoma brucei by forming an adduct with trypanothione.
Hodoodo Cat#: H562618
Name: AS-HK014
CAS#: 128700-97-0
Chemical Formula: C21H24O5
Exact Mass: 356.16
Molecular Weight: 356.418
Elemental Analysis: C, 70.77; H, 6.79; O, 22.44
Synonym: AS-HK014; AS HK014; ASHK014; Gingerenone A; Gingerenone-A;
IUPAC/Chemical Name: (4E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-4-hepten-3-one
InChi Key: FWDXZNKYDTXGOT-GQCTYLIASA-N
InChi Code: InChI=1S/C21H24O5/c1-25-20-13-15(8-11-18(20)23)5-3-4-6-17(22)10-7-16-9-12-19(24)21(14-16)26-2/h4,6,8-9,11-14,23-24H,3,5,7,10H2,1-2H3/b6-4+
SMILES Code: O=C(/C=C/CCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2
Appearance: A solution in ethanol
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 356.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Alkhaldi AA, Creek DJ, Ibrahim H, Kim DH, Quashie NB, Burgess KE, Changtam C, Barrett MP, Suksamrarn A, de Koning HP. Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on trypanosoma brucei by forming an adduct with trypanothione. Mol Pharmacol. 2015;87(3):451-64. doi: 10.1124/mol.114.096016. Epub 2014 Dec 19. PubMed PMID: 25527638.
