Acetylcholine chloride
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Hodoodo CAT#: H571549

CAS#: 60-31-1 (chloride)

Description: Acetylcholine chloride is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.


Chemical Structure

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Acetylcholine chloride
CAS# 60-31-1 (chloride)

Theoretical Analysis

Hodoodo Cat#: H571549
Name: Acetylcholine chloride
CAS#: 60-31-1 (chloride)
Chemical Formula: C7H16ClNO2
Exact Mass: 0.00
Molecular Weight: 181.660
Elemental Analysis: C, 46.28; H, 8.88; Cl, 19.51; N, 7.71; O, 17.61

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500g USD 930
100g USD 950
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Related CAS #: 60-31-1 (chloride)   51-84-3 (cation)    

Synonym: Ovisot; TL 1505; TL-1505; TL-1505; Acetylcholine chloride.

IUPAC/Chemical Name: (2-Acetoxyethyl)trimethylammonium chloride

InChi Key: JUGOREOARAHOCO-UHFFFAOYSA-M

InChi Code: InChI=1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

SMILES Code: C[N+](C)(CCOC(C)=O)C.[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 181.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Figueiredo C, Grilo TF, Lopes C, Brito P, Diniz M, Caetano M, Rosa R, Raimundo J. Accumulation, elimination and neuro-oxidative damage under lanthanum exposure in glass eels (Anguilla anguilla). Chemosphere. 2018 May 7;206:414-423. doi: 10.1016/j.chemosphere.2018.05.029. [Epub ahead of print] PubMed PMID: 29758498.

2: Marees AT, Hammerschlag AR, Bastarache L, de Kluiver H, Vorspan F, van den Brink W, Smit DJ, Denys D, Gamazon ER, Li-Gao R, Breetvelt EJ, de Groot MCH, Galesloot TE, Vermeulen SH, Poppelaars JL, Souverein PC, Keeman R, de Mutsert R, Noordam R, Rosendaal FR, Stringa N, Mook-Kanamori DO, Vaartjes I, Kiemeney LA, den Heijer M, van Schoor NM, Klungel OH, Maitland-Van der Zee AH, Schmidt MK, Polderman TJC, van der Leij AR, Posthuma D, Derks EM. Exploring the role of low-frequency and rare exonic variants in alcohol and tobacco use. Drug Alcohol Depend. 2018 Apr 25;188:94-101. doi: 10.1016/j.drugalcdep.2018.03.026. [Epub ahead of print] PubMed PMID: 29758381.

3: Sethuramanujam S, Awatramani GB, Slaughter MM. Cholinergic excitation complements glutamate in coding visual information in retinal ganglion cells. J Physiol. 2018 May 14. doi: 10.1113/JP275073. [Epub ahead of print] PubMed PMID: 29758086.

4: Wu J, Chen B, Li W, Xiao Y. Effects of Nerve Growth Factor shRNA Inhibition on Asthma Phenotypes in a Mouse Model of Asthma. Iran J Allergy Asthma Immunol. 2018 Apr;17(2):110-122. PubMed PMID: 29757584.

5: Mishra RC, Rahman MM, Davis MJ, Wulff H, Hill MA, Braun AP. Alpha(1) -adrenergic stimulation selectively enhances endothelium-mediated vasodilation in rat cremaster arteries. Physiol Rep. 2018 May;6(9):e13703. doi: 10.14814/phy2.13703. PubMed PMID: 29756401.

6: Li SP, Wang YW, Qi SL, Zhang YP, Deng G, Ding WZ, Ma C, Lin QY, Guan HD, Liu W, Cheng XM, Wang CH. Analogous β-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice. Front Pharmacol. 2018 Apr 10;9:346. doi: 10.3389/fphar.2018.00346. eCollection 2018. PubMed PMID: 29755345; PubMed Central PMCID: PMC5932362.

7: Bertron JL, Cho HP, Garcia-Barrantes PM, Panarese JD, Salovich JM, Nance KD, Engers DW, Rook JM, Blobaum AL, Niswender CM, Stauffer SR, Conn PJ, Lindsley CW. The discovery of VU0486846: steep SAR from a series of M(1) PAMs based on a novel benzomorpholine core. Bioorg Med Chem Lett. 2018 May 5. pii: S0960-894X(18)30399-8. doi: 10.1016/j.bmcl.2018.05.009. [Epub ahead of print] PubMed PMID: 29754948.

8: Wunpathe C, Potue P, Maneesai P, Bunbupha S, Prachaney P, Kukongviriyapan U, Kukongviriyapan V, Pakdeechote P. Hesperidin Suppresses Renin-Angiotensin System Mediated NOX2 Over-Expression and Sympathoexcitation in 2K-1C Hypertensive Rats. Am J Chin Med. 2018 May 13:1-17. doi: 10.1142/S0192415X18500398. [Epub ahead of print] PubMed PMID: 29754503.

9: Wan Y, Yuan G, He B, Xu B, Xie W, Wang S, Zhang Y, Wu Q, Zhou X. Foccα6, a truncated nAChR subunit, positively correlates with spinosad resistance in the western flower thrips, Frankliniella occidentalis (Pergande). Insect Biochem Mol Biol. 2018 May 10. pii: S0965-1748(18)30182-6. doi: 10.1016/j.ibmb.2018.05.002. [Epub ahead of print] PubMed PMID: 29753712.

10: Borges JP, Mendes FSNS, Lopes GO, Sousa AS, Mediano MFF, Tibiriçá E. Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy? Int J Cardiol. 2018 May 1. pii: S0167-5273(17)37160-7. doi: 10.1016/j.ijcard.2018.04.133. [Epub ahead of print] PubMed PMID: 29753516.

11: Khaddaj-Mallat R, John CM, Braun AP. SKA-31, an activator of endothelial Ca(2+)-activated K(+) channels evokes robust vasodilation in rat mesenteric arteries. Eur J Pharmacol. 2018 May 9. pii: S0014-2999(18)30262-0. doi: 10.1016/j.ejphar.2018.05.006. [Epub ahead of print] PubMed PMID: 29753043.

12: Leong IL, Tsai TY, Wong KL, Shiao LR, Cheng KS, Chan P, Leung YM. Valproic acid inhibits ATP-triggered Ca(2+) release via a p38- dependent mechanism in bEND.3 endothelial cells. Fundam Clin Pharmacol. 2018 May 12. doi: 10.1111/fcp.12381. [Epub ahead of print] PubMed PMID: 29752814.

13: Cescon M, Gregorio I, Eiber N, Borgia D, Fusto A, Sabatelli P, Scorzeto M, Megighian A, Pegoraro E, Hashemolhosseini S, Bonaldo P. Collagen VI is required for the structural and functional integrity of the neuromuscular junction. Acta Neuropathol. 2018 May 11. doi: 10.1007/s00401-018-1860-9. [Epub ahead of print] PubMed PMID: 29752552.

14: Aydin B, Guvenc G, Altinbas B, Niaz N, Yalcin M. Modulation of nesfatin-1-induced cardiovascular effects by the central cholinergic system. Neuropeptides. 2018 May 4. pii: S0143-4179(18)30038-6. doi: 10.1016/j.npep.2018.05.001. [Epub ahead of print] PubMed PMID: 29751997.

15: Selya AS, Cannon DS, Weiss RB, Wakschlag LS, Rose JS, Dierker L, Hedeker D, Mermelstein RJ. The role of nicotinic receptor genes (CHRN) in the pathways of prenatal tobacco exposure on smoking behavior among young adult light smokers. Addict Behav. 2018 May 3;84:231-237. doi: 10.1016/j.addbeh.2018.05.001. [Epub ahead of print] PubMed PMID: 29751336.

16: Deligia F, Murineddu G, Gotti C, Ragusa G, Fasoli F, Sciaccaluga M, Plutino S, Fucile S, Loriga G, Asproni B, Pinna GA. Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for α(4)β(2) nACh receptors. Eur J Med Chem. 2018 Apr 17;152:401-416. doi: 10.1016/j.ejmech.2018.04.026. [Epub ahead of print] PubMed PMID: 29751234.

17: Jacobson SW, Carter RC, Molteno CD, Meintjes EM, Senekal M, Lindinger NM, Dodge NC, Zeisel SH, Duggan CP, Jacobson JL. Feasibility and acceptability of maternal choline supplementation in heavy drinking pregnant women: A randomized, double-blind, placebo-controlled clinical trial. Alcohol Clin Exp Res. 2018 May 11. doi: 10.1111/acer.13768. [Epub ahead of print] PubMed PMID: 29750366.

18: Briguglio M, Dell'Osso B, Panzica G, Malgaroli A, Banfi G, Zanaboni Dina C, Galentino R, Porta M. Dietary Neurotransmitters: A Narrative Review on Current Knowledge. Nutrients. 2018 May 10;10(5). pii: E591. doi: 10.3390/nu10050591. Review. PubMed PMID: 29748506.

19: Martin AA, Richmond JE. The sarco(endo)plasmic reticulum calcium ATPase SCA-1 regulates the Caenorhabditis elegans nicotinic acetylcholine receptor ACR-16. Cell Calcium. 2018 Feb 24;72:104-115. doi: 10.1016/j.ceca.2018.02.005. [Epub ahead of print] PubMed PMID: 29748129.

20: Siasos G, Sara JD, Zaromytidou M, Park KH, Coskun AU, Lerman LO, Oikonomou E, Maynard CC, Fotiadis D, Stefanou K, Papafaklis M, Michalis L, Feldman C, Lerman A, Stone PH. Local Low Shear Stress and Endothelial Dysfunction in Patients With Nonobstructive Coronary Atherosclerosis. J Am Coll Cardiol. 2018 May 15;71(19):2092-2102. doi: 10.1016/j.jacc.2018.02.073. PubMed PMID: 29747829.