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Pentachlorophenol
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H591045

CAS#: 87-86-5

Description: Pentachlorophenol is an insecticide and herbicide that has also been used as a wood preservative. Pentachlorphenol is a widespread environmental pollutant. Both chronic and acute pentachlorophenol poisoning are medical concerns. The range of its biological actions is still being actively explored, but it is clearly a potent enzyme inhibitor.

Chemical Structure

Pentachlorophenol

CAS# 87-86-5

Instruction

Theoretical Analysis

Hodoodo Cat#: H591045
Name: Pentachlorophenol
CAS#: 87-86-5
Chemical Formula: C6HCl5O
Exact Mass: 263.85
Molecular Weight: 266.320
Elemental Analysis: C, 27.06; H, 0.38; Cl, 66.55; O, 6.01

Price and Availability

Size	Price	Availability	Quantity
5g	USD 350	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Peratox; Permacide; Permagard; Permasan

IUPAC/Chemical Name: Phenol, 2,3,4,5,6-pentachloro-

InChi Key: IZUPBVBPLAPZRR-UHFFFAOYSA-N

InChi Code: InChI=1S/C6HCl5O/c7-1-2(8)4(10)6(12)5(11)3(1)9/h12H

SMILES Code: OC1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 266.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hua X, Wang L, Zhang L, Dong D, Guo Z. Effects of heavy metal species, concentrations, and speciation on pentachlorophenol sorption by river biofilms. Environ Sci Pollut Res Int. 2018 May 13. doi: 10.1007/s11356-018-2261-2. [Epub ahead of print] PubMed PMID: 29756183.

2: Yang K, Fu ZW, Cao YF, Li SN, Du Z, Sun XY, Liu YZ, Yang K, Fang ZZ. New insights for risks of chlorophenols (CPs) exposure: Inhibition of UDP-glucuronosyltransferases (UGTs). Chemosphere. 2018 Apr 24;206:9-16. doi: 10.1016/j.chemosphere.2018.04.148. [Epub ahead of print] PubMed PMID: 29723751.

3: Gunawardana B, Swedlund PJ, Singhal N, Nieuwoudt MK. Pentachlorophenol dechlorination with zero valent iron: a Raman and GCMS study of the complex role of surficial iron oxides. Environ Sci Pollut Res Int. 2018 Apr 20. doi: 10.1007/s11356-018-2003-5. [Epub ahead of print] PubMed PMID: 29675820.

4: Edo M, Ortuño N, Persson PE, Conesa JA, Jansson S. Emissions of toxic pollutants from co-combustion of demolition and construction wood and household waste fuel blends. Chemosphere. 2018 Jul;203:506-513. doi: 10.1016/j.chemosphere.2018.03.203. Epub 2018 Apr 4. PubMed PMID: 29649692.

5: Xu Y, Xue L, Ye Q, Franks AE, Zhu M, Feng X, Xu J, He Y. Inhibitory Effects of Sulfate and Nitrate Reduction on Reductive Dechlorination of PCP in a Flooded Paddy Soil. Front Microbiol. 2018 Mar 28;9:567. doi: 10.3389/fmicb.2018.00567. eCollection 2018. PubMed PMID: 29643842; PubMed Central PMCID: PMC5882776.

6: Abualfaraj N, Gurian PL, Olson MS. Assessing Residential Exposure Risk from Spills of Flowback Water from Marcellus Shale Hydraulic Fracturing Activity. Int J Environ Res Public Health. 2018 Apr 11;15(4). pii: E727. doi: 10.3390/ijerph15040727. PubMed PMID: 29641504; PubMed Central PMCID: PMC5923769.

7: Moreno-Paz M, Gómez-Cifuentes A, Ruiz-Bermejo M, Hofstetter O, Maquieira Á, Manchado JM, Morais S, Sephton MA, Niessner R, Knopp D, Parro V. Detecting Nonvolatile Life- and Nonlife-Derived Organics in a Carbonaceous Chondrite Analogue with a New Multiplex Immunoassay and Its Relevance for Planetary Exploration. Astrobiology. 2018 Apr 11. doi: 10.1089/ast.2017.1747. [Epub ahead of print] PubMed PMID: 29638146.

8: Zhu M, Zhang L, Zheng L, Zhuo Y, Xu J, He Y. Typical Soil Redox Processes in Pentachlorophenol Polluted Soil Following Biochar Addition. Front Microbiol. 2018 Mar 27;9:579. doi: 10.3389/fmicb.2018.00579. eCollection 2018. PubMed PMID: 29636746; PubMed Central PMCID: PMC5880936.

9: Beiras R, Tato T. Marine environmental risk assessment and acute water quality criterion for pentachlorophenol in coastal waters. Ecotoxicology. 2018 Apr 7. doi: 10.1007/s10646-018-1930-8. [Epub ahead of print] PubMed PMID: 29627908.

10: Bellamri M, Xiao S, Murugan P, Weight CJ, Turesky RJ. Metabolic activation of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in human prostate. Toxicol Sci. 2018 Mar 27. doi: 10.1093/toxsci/kfy060. [Epub ahead of print] PubMed PMID: 29596660.

11: Mikkonen A, Yläranta K, Tiirola M, Dutra LAL, Salmi P, Romantschuk M, Copley S, Ikäheimo J, Sinkkonen A. Successful aerobic bioremediation of groundwater contaminated with higher chlorinated phenols by indigenous degrader bacteria. Water Res. 2018 Jul 1;138:118-128. doi: 10.1016/j.watres.2018.03.033. Epub 2018 Mar 13. PubMed PMID: 29574199.

12: Douwes J, 't Mannetje A, McLean D, Pearce N, Woodward A, Potter JD. Carcinogenicity of glyphosate: why is New Zealand's EPA lost in the weeds? N Z Med J. 2018 Mar 23;131(1472):82-89. PubMed PMID: 29565939.

13: Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis. 2018 Apr 5;39(4):614-622. doi: 10.1093/carcin/bgy031. PubMed PMID: 29562322; PubMed Central PMCID: PMC5888955.

14: Ikeda M, Deguchi J, Fukushima S, Qingyu A, Katayama N, Miura H, Oyama Y. Some adverse actions of chlorothalonil at sublethal levels in rat thymic lymphocytes: Its relation to Zn(2). Environ Toxicol Pharmacol. 2018 Apr;59:61-65. doi: 10.1016/j.etap.2018.03.006. Epub 2018 Mar 8. PubMed PMID: 29544185.

15: El-Bialy HA, Khalil OAA, Gomaa OM. Bacterial-mediated biodegradation of pentachlorophenol via electron shuttling. Environ Technol. 2018 Mar 1:1-9. doi: 10.1080/09593330.2018.1442501. [Epub ahead of print] PubMed PMID: 29455620.

16: Lewandowski KK, Cieślikiewicz W, Kobusińska ME, Niemirycz E. Sorption of pentachlorophenol (PCP) in the marine bottom sediments-batch sorption experiment at varying pressure. Environ Sci Pollut Res Int. 2018 Apr;25(11):10799-10807. doi: 10.1007/s11356-017-1076-x. Epub 2018 Feb 2. PubMed PMID: 29396827; PubMed Central PMCID: PMC5895666.

17: Ma HY, Zhao L, Wang DB, Zhang H, Guo LH. Dynamic Tracking of Highly Toxic Intermediates in Photocatalytic Degradation of Pentachlorophenol by Continuous Flow Chemiluminescence. Environ Sci Technol. 2018 Mar 6;52(5):2870-2877. doi: 10.1021/acs.est.7b05518. Epub 2018 Feb 14. PubMed PMID: 29394042.

18: Pan S, Chen X, He Q, Li X, Wang L, Zhou J, Jin M. [Confirmation and analysis of the metabolites of pentachlorophenol in loaches using ultra-performance liquid chromatography-high resolution mass spectrometry]. Se Pu. 2017 Dec 8;35(12):1245-1250. doi: 10.3724/SP.J.1123.2017.09012. Chinese. PubMed PMID: 29372774.

19: Zhu B, Shen C, Gao H, Zhu L, Shao J, Mao L. Intrinsic chemiluminescence production from the degradation of haloaromatic pollutants during environmentally-friendly advanced oxidation processes: Mechanism, structure-activity relationship and potential applications. J Environ Sci (China). 2017 Dec;62:68-83. doi: 10.1016/j.jes.2017.06.035. Epub 2017 Jul 14. Review. PubMed PMID: 29289294.

20: Chen L, Krol ES, Sakharkar MK, Khan HA, Alhomida AS, Yang J. Residues His172 and Lys238 are Essential for the Catalytic Activity of the Maleylacetate Reductase from Sphingobium chlorophenolicum Strain L-1. Sci Rep. 2017 Dec 22;7(1):18097. doi: 10.1038/s41598-017-18475-8. PubMed PMID: 29273747; PubMed Central PMCID: PMC5741723.

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