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Isothipendyl hydrochloride
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H591079

CAS#: 1225-60-1

Description: Isothipendyl hydrochloride is a 1st generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic.

Chemical Structure

Isothipendyl hydrochloride

CAS# 1225-60-1

Instruction

Theoretical Analysis

Hodoodo Cat#: H591079
Name: Isothipendyl hydrochloride
CAS#: 1225-60-1
Chemical Formula: C16H20ClN3S
Exact Mass: 321.11
Molecular Weight: 321.870
Elemental Analysis: C, 59.71; H, 6.26; Cl, 11.01; N, 13.06; S, 9.96

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 350	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Isothipendyl hydrochloride; NSC 169186; NSC-169186; NSC169186

IUPAC/Chemical Name: 10-(2-Dimethylaminopropyl)-10H-pyrido(3,2-b)(1,4)benzothiazine hydrochloride

InChi Key: RQHCFTORMXCNGP-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H19N3S.ClH/c1-12(18(2)3)11-19-13-7-4-5-8-14(13)20-15-9-6-10-17-16(15)19;/h4-10,12H,11H2,1-3H3;1H

SMILES Code: CC(N(C)C)CN1C2=NC=CC=C2SC3=CC=CC=C13.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 321.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bibas N, Sartor V, Bulai Livideanu C, Bagheri H, Nougué J, Giordano-Labadie F, Maza A, Paul C, Chouini-Lalanne N, Marguery MC. Contact photoallergy to isothipendyl chlorhydrate. Dermatology. 2012;224(4):289-91. doi: 10.1159/000338024. Epub 2012 Jun 1. PubMed PMID: 22677929.

2: Melwanki MB, Seetharamappa J. Spectrophotometric studies on the investigation of chromium in environmental samples. Indian J Environ Health. 2003 Jan;45(1):25-8. PubMed PMID: 14723280.

3: Gowda BG, Seetharamappa J. Extractive spectrophotometric determination of fluoroquinolones and antiallergic drugs in pure and pharmaceutical formulations. Anal Sci. 2003 Mar;19(3):461-4. PubMed PMID: 12675360.

4: Melwanki MB, Seetharamappa J, Masti SP. Spectrophotometric determination of molybdenum(VI) using isothipendyl hydrochloride and pipazethate hydrochloride in alloy steels and soil samples. Anal Sci. 2001 Sep;17(9):1121-3. PubMed PMID: 11708072.

5: Moreau A, Dompmartin A, Dubreuil A, Leroy D. Phototoxic and photoprotective effects of topical isothipendyl. Photodermatol Photoimmunol Photomed. 1995 Apr;11(2):50-4. PubMed PMID: 8546983.

6: Kinnamon KE, Klayman DL, Poon BT, McCall JW, Dzimianski MT, Rowan SJ. Filariasis testing in a jird model: new drug leads from some old standbys. Am J Trop Med Hyg. 1994 Dec;51(6):791-6. PubMed PMID: 7810813.

7: Abdel-Hay MH, Elsayed MA, Barary MH, Hassan EM. Determination of isothipendyl or dimethothiazine with their sulphoxides using third- and fourth-derivatives spectroscopy on a diode-array spectrophotometer. J Pharm Belg. 1990 Jul-Aug;45(4):259-67. PubMed PMID: 2290121.

8: Maurer H, Pfleger K. Identification of phenothiazine antihistamines and their metabolites in urine. Arch Toxicol. 1988;62(2-3):185-91. PubMed PMID: 2904251.

9: Takashima Y, Tanaka S, Hosono S, Kawamata I, Murayama H. [Distribution of isothipendyl in O/W type creams and its release]. Yakugaku Zasshi. 1985 Feb;105(2):166-70. Japanese. PubMed PMID: 2861270.

10: Takashima A, Yoshikawa K. Contact allergy to isothipendyl. Contact Dermatitis. 1983 Sep;9(5):429-30. PubMed PMID: 6138212.

11: Bartsch W, Dietmann K, Nothdurft H. [Pharmacologic experience on the effects of antihistaminic isothipendyl hydrochloride combined with calcium gluconate]. Hospital (Rio J). 1969 Jan;75(1):187-99. Portuguese. PubMed PMID: 4387989.

12: INADA T, HONGO H, KITAYAMA T, MATSUO M. [THE USE OF ANDANTOL IN THE TREATMENT OF ALLERGIC DISEASES AT UROLOGICAL CLINIC]. Hinyokika Kiyo. 1964 Apr;10:226-33. Japanese. PubMed PMID: 14157559.

13: KATO H, YUGAWA S, MESHITSUKA T, IMAKUMI T, TAMURA T, OKI K, YAMAKAWA N. [Use of Andantol jelly in diseases of the ear, nose and throat]. Jibiinkoka. 1962 Jun;34:519-23. Japanese. PubMed PMID: 14454251.

14: OSAWA R, NAKAMURA M. [Experience in the use of Andantol jelly in the field of otorhinolaryngology]. Jibiinkoka. 1962 Feb;34:163-5. Japanese. PubMed PMID: 14482447.

15: DISSARD P. [Indications for suppositories with antihistaminic (Andantol) base in the treatment of hemorrhoidal anitis]. Lyon Med. 1962 Jan 28;94:181-6. French. PubMed PMID: 13886583.

16: TAKAHASI A. [Cure of several pruritic skin diseases with Andantol jelly]. Hifuka Kiyo. 1962 Jan;57:91-5. Japanese. PubMed PMID: 13919102.

17: OFUJI S, MATSUO T. [The clinical effect of Andantol jelly for pruritic skin diseases]. Hifuka Kiyo. 1961 Nov;56:361-2. Japanese. PubMed PMID: 14481215.

18: YANAGIHARA M, MATSUSAKA Y, HAMADA K. [The clinical effect of Andantol jelly]. Hifuka Kiyo. 1961 Nov;56:363-6. Japanese. PubMed PMID: 14008937.

19: SCHROEDER H, HUTSCHENREUTER K. [Experiences with andantol jelly in local therapy of superficial burns]. Med Welt. 1961 Sep 2;35:1788-90. German. PubMed PMID: 13748665.

20: UHR L, MILLER JG. An experimental study of the behavioral effects of isothipendyl hydrochloride (Theruhistin). Acta Allergol. 1961;16:141-50. PubMed PMID: 13779032.

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Isothipendyl hydrochloride featured