WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H591105
CAS#: 96328-17-5
Description: Adechlorin is synergistic antitumor and/or antiviral antibiotic which potentiate the effects of other antitumor or antiviral compounds through inhibition of key enzymes such as adenosine deaminase
Hodoodo Cat#: H591105
Name: Adechlorin
CAS#: 96328-17-5
Chemical Formula: C11H15ClN4O4
Exact Mass: 302.08
Molecular Weight: 302.720
Elemental Analysis: C, 43.65; H, 4.99; Cl, 11.71; N, 18.51; O, 21.14
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Adechlorin;
IUPAC/Chemical Name: Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-chloro-2-deoxy-beta-D-ribofuranosyl)-3,4,7,8-tetrahydro-, (R)-
InChi Key: JYWSHPMZFVPRRF-AMFMTJJISA-N
InChi Code: InChI=1S/C11H15ClN4O4/c12-7-9(19)6(2-17)20-11(7)16-4-15-8-5(18)1-13-3-14-10(8)16/h3-7,9,11,17-19H,1-2H2,(H,13,14)/t5-,6-,7-,9-,11-/m1/s1
SMILES Code: O[C@H]1C2=C(N([C@H]3[C@H](Cl)[C@@H]([C@@H](CO)O3)O)C=N2)NC=NC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 302.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Gao Y, Xu G, Wu P, Liu J, Cai YS, Deng Z, Chen W. Biosynthesis of 2'-Chloropentostatin and 2'-Amino-2'-Deoxyadenosine Highlights a Single Gene Cluster Responsible for Two Independent Pathways in Actinomadura sp. Strain ATCC
39365. Appl Environ Microbiol. 2017 May 1;83(10). pii: e00078-17. doi: 10.1128/AEM.00078-17. Print 2017 May 15. PubMed PMID: 28258148; PubMed Central PMCID: PMC5411499.
2: Hosmane RS. Ring-expanded ("Fat") nucleosides as broad-spectrum anticancer and antiviral agents. Curr Top Med Chem. 2002 Oct;2(10):1093-109. Review. PubMed PMID: 12173969.
3: Suhadolnik RJ, Pornbanlualap S, Baker DC, Tiwari KN, Hebbler AK. Stereospecific 2'-amination and 2'-chlorination of adenosine by Actinomadura in the biosynthesis of 2'-amino-2'-deoxyadenosine and 2'-chloro-2'-deoxycoformycin.
Arch Biochem Biophys. 1989 Apr;270(1):374-82. PubMed PMID: 2784655.
4: Jackson RC, Leopold WR, Ross DA. The biochemical pharmacology of (2'-R)-chloropentostatin, a novel inhibitor of adenosine deaminase. Adv Enzyme Regul. 1986;25:125-39. PubMed PMID: 2433905.
5: Tunac JB, Underhill M. 2'-Chloropentostatin: discovery, fermentation and biological activity. J Antibiot (Tokyo). 1985 Oct;38(10):1344-9. PubMed PMID: 3934118.
6: Omura S, Imamura N, Kuga H, Ishikawa H, Yamazaki Y, Okano K, Kimura K, Takahashi Y, Tanaka H. Adechlorin, a new adenosine deaminase inhibitor containing chlorine production, isolation and properties. J Antibiot (Tokyo). 1985 Aug;38(8):1008-15. PubMed PMID: 3840153.
