WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562773
CAS#: 92407-91-5
Description: NSC-741909 is an anticancer agent. It acts by suppressing the growth of several cell lines derived from lung, colon, breast, ovarian, and kidney cancers.
Hodoodo Cat#: H562773
Name: NSC-741909
CAS#: 92407-91-5
Chemical Formula: C16H14ClNO
Exact Mass: 271.08
Molecular Weight: 271.740
Elemental Analysis: C, 70.72; H, 5.19; Cl, 13.05; N, 5.15; O, 5.89
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Synonym: NSC-741909; NSC 741909; NSC741909;
IUPAC/Chemical Name: [1-[(4-chlorophenyl)methyl]indol-3-yl]methanol
InChi Key: WOUBLGRNDINCJL-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H14ClNO/c17-14-7-5-12(6-8-14)9-18-10-13(11-19)15-3-1-2-4-16(15)18/h1-8,10,19H,9,11H2
SMILES Code: OCC1=CN(CC2=CC=C(Cl)C=C2)C3=C1C=CC=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 271.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Guo W, Wu S, Wang L, Wei X, Liu X, Wang J, Lu Z, Hollingshead M, Fang B. Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition. PLoS One. 2011;6(12):e28487. doi: 10.1371/journal.pone.0028487. Epub 2011 Dec 12. PubMed PMID: 22174819; PubMed Central PMCID: PMC3236185.
2: Guo W, Wei X, Wu S, Wang L, Peng H, Wang J, Fang B. Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species. Eur J Pharmacol. 2010 Dec 15;649(1-3):51-8. doi: 10.1016/j.ejphar.2010.08.057. Epub 2010 Sep 18. PubMed PMID: 20854805; PubMed Central PMCID: PMC2967662.
3: Wei X, Guo W, Wu S, Wang L, Huang P, Liu J, Fang B. Oxidative stress in NSC-741909-induced apoptosis of cancer cells. J Transl Med. 2010 Apr 16;8:37. doi: 10.1186/1479-5876-8-37. PubMed PMID: 20398386; PubMed Central PMCID: PMC2873373.
4: Wei X, Guo W, Wu S, Wang L, Lu Y, Xu B, Liu J, Fang B. Inhibiting JNK dephosphorylation and induction of apoptosis by novel anticancer agent NSC-741909 in cancer cells. J Biol Chem. 2009 Jun 19;284(25):16948-55. doi: 10.1074/jbc.M109.010256. Epub 2009 May 4. PubMed PMID: 19414586; PubMed Central PMCID: PMC2719332.