LF3
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H584436

CAS#: 664969-54-4

Description: LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM.

Chemical Structure

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LF3
CAS# 664969-54-4
Instruction

Theoretical Analysis

Hodoodo Cat#: H584436
Name: LF3
CAS#: 664969-54-4
Chemical Formula: C20H24N4O2S2
Exact Mass: 416.13
Molecular Weight: 416.558
Elemental Analysis: C, 57.67; H, 5.81; N, 13.45; O, 7.68; S, 15.39

Price and Availability

Size Price Availability Quantity
10mg USD 250 2 Weeks
25mg USD 450 2 Weeks
50mg USD 750 2 Weeks
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Synonym: LF3

IUPAC/Chemical Name: 1-Piperazinecarbothioamide, N-[4-(aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)-

InChi Key: ZUQIFHLBPBLRRM-QPJJXVBHSA-N

InChi Code: InChI=1S/C20H24N4O2S2/c21-28(25,26)19-10-8-18(9-11-19)22-20(27)24-15-13-23(14-16-24)12-4-7-17-5-2-1-3-6-17/h1-11H,12-16H2,(H,22,27)(H2,21,25,26)/b7-4+

SMILES Code: S=C(N1CCN(C/C=C/C2=CC=CC=C2)CC1)NC3=CC=C(S(=O)(N)=O)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 416.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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[1] Fang L, et al. Cancer Res. 2016, 76(4):891-901.