WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H591166
CAS#: 548-66-3
Description: Drofenine hydrochloride is a widely used anticholinergic drug. It acts on smooth muscle to inhibit muscle spasms.
Hodoodo Cat#: H591166
Name: Drofenine hydrochloride
CAS#: 548-66-3
Chemical Formula: C20H32ClNO2
Exact Mass: 353.21
Molecular Weight: 353.931
Elemental Analysis: C, 67.87; H, 9.11; Cl, 10.02; N, 3.96; O, 9.04
Synonym: Cycloadiphenine hydrochloride, Cyclohexylphenylacetyldiethylaminoethanol hydrochloride, Cyclospasmol (tempelhof), Cyclovegantine, Drofenine HCl, Drofenine hydrochloride; Hexahydroadiphenine hydrochloride, IT-19, NSC 42559, Profenene hydrochloride, Trasentin H, Trasentine A, Trasentine-A
IUPAC/Chemical Name: Benzeneacetic acid, alpha-cyclohexyl-, 2-(diethylamino)ethyl ester, hydrochloride (9CI)
InChi Key: WIELVDXKOYPANK-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H31NO2.ClH/c1-3-21(4-2)15-16-23-20(22)19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5,7-8,11-12,18-19H,3-4,6,9-10,13-16H2,1-2H3;1H
SMILES Code: O=C(OCCN(CC)CC)C(C1CCCCC1)C2=CC=CC=C2.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 353.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Facchini G, Zaccheo F, Nannetti M. Simultaneous determination of hydrochloride salts of adiphenine, diphenhydramine, ethyldiphenacetate, drofenine and promazine by ion-pair HPLC. Boll Chim Farm. 1983 Aug;122(8):405-11. PubMed PMID: 6140928.
2: Pawelczyk E, Hermann T, Marciniec B, Pluta I. Studies on kinetics of degradation of drugs. XIX. Thermic degradation of aminophenazone (AP), allobarbital (AB), cycloadiphenine hydrochloride (CAD) mixture in cetyl phtalate medium. Acta Pol Pharm. 1971;28(6):594-602. PubMed PMID: 5163824.