WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562843
CAS#: 1242279-00-0
Description: WF-210 is a potent activator of procaspase-3. It acts by inducing apoptosis in cancer cells and reducing tumor growth in human breast, liver and gallbladder cancer xenografts.
Hodoodo Cat#: H562843
Name: WF-210
CAS#: 1242279-00-0
Chemical Formula: C41H38FN7O7S
Exact Mass: 791.25
Molecular Weight: 791.850
Elemental Analysis: C, 62.19; H, 4.84; F, 2.40; N, 12.38; O, 14.14; S, 4.05
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Synonym: WF-210; WF 210; WF210;
IUPAC/Chemical Name: 4-[[3-[4-[(4-Fluorophenoxy)methyl]phenyl]-1,2,4-oxadiazol-5-yl]methyl]-1-piperazineacetic acid 2-[[4-[[2-(1,3-benzodioxol-5-ylmethyl)-4-thiazolyl]methoxy]-2-hydroxyphenyl]methylene]hydrazide
InChi Key: UBTUDBNKVUIOLS-PZUSPJSTSA-N
InChi Code: InChI=1S/C41H38FN7O7S/c42-31-7-10-33(11-8-31)52-23-27-1-4-29(5-2-27)41-45-39(56-47-41)22-49-15-13-48(14-16-49)21-38(51)46-43-20-30-6-9-34(19-35(30)50)53-24-32-25-57-40(44-32)18-28-3-12-36-37(17-28)55-26-54-36/h1-12,17,19-20,25,50H,13-16,18,21-24,26H2,(H,46,51)/b43-20+
SMILES Code: O=C(N/N=C/C1=CC=C(OCC2=CSC(CC3=CC=C(OCO4)C4=C3)=N2)C=C1O)CN5CCN(CC6=NC(C7=CC=C(COC8=CC=C(F)C=C8)C=C7)=NO6)CC5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 791.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Wang F, Wang L, Li Y, Wang N, Wang Y, Cao Q, Gong P, Yang J, Wu C. PAC-1 and its derivative WF-210 Inhibit Angiogenesis by inhibiting VEGF/VEGFR pathway. Eur J Pharmacol. 2018 Feb 15;821:29-38. doi: 10.1016/j.ejphar.2017.12.035. Epub 2017 Dec 19. PubMed PMID: 29269017.
2: Wang F, Wang L, Zhao Y, Li Y, Ping G, Xiao S, Chen K, Zhu W, Gong P, Yang J, Wu C. A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts. Mol Oncol. 2014 Dec;8(8):1640-52. doi: 10.1016/j.molonc.2014.06.015. Epub 2014 Jul 3. PubMed PMID: 25053517; PubMed Central PMCID: PMC5528581.
