WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H591318
CAS#: 3691-35-8
Description: Chlorophacinone is an anticoagulant used as a rodenticide.
Hodoodo Cat#: H591318
Name: Chlorophacinone
CAS#: 3691-35-8
Chemical Formula: C17H11CL93
Exact Mass: 298.04
Molecular Weight: 298.720
Elemental Analysis: C, 68.35; H, 3.71; Cl, 11.87; O, 16.07
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Chlorophacinone;
IUPAC/Chemical Name: 2-(alpha-p-Chlorophenylacetyl)indane-1,3-dione
InChi Key: XYVDRRBGKJBTLI-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H11ClO3/c18-11-7-5-10(6-8-11)9-14(19)15-16(20)12-3-1-2-4-13(12)17(15)21/h1-8,15H,9H2
SMILES Code: O=C1C(C(CC2=CC=C(Cl)C=C2)=O)C(C3=C1C=CC=C3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 298.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Qiao Z, Xiang P, Shen B, Shen M, Yan H. Simultaneous Determination of 13 Anticoagulant Rodenticidesin Human Blood by Liquid Chromatography-Tandem Mass Spectrometry and its Application in Three Poisoning Cases. J Forensic Sci. 2018 May;63(3):784-792. doi: 10.1111/1556-4029.13613. PubMed PMID: 29723420.
2: D'Alessio M, Wang T, Swift CE, Shanmungam MS, Ray C. A Tier-I leaching risk assessment of three anticoagulant compounds in the forested areas of Hawai'i. Sci Total Environ. 2018 Jul 15;630:889-902. doi: 10.1016/j.scitotenv.2018.02.257. Epub 2018 Mar 7. PubMed PMID: 29499544.
3: Alomar H, Chabert A, Coeurdassier M, Vey D, Berny P. Accumulation of anticoagulant rodenticides (chlorophacinone, bromadiolone and brodifacoum) in a non-target invertebrate, the slug, Deroceras reticulatum. Sci Total Environ. 2018 Jan 1;610-611:576-582. doi: 10.1016/j.scitotenv.2017.08.117. Epub 2017 Aug 17. PubMed PMID: 28822925.
4: Smith LL, Liang B, Booth MC, Filigenzi MS, Tkachenko A, Gaskill CL. Development and Validation of Quantitative Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry Assay for Anticoagulant Rodenticides in Liver. J Agric Food Chem. 2017 Aug 9;65(31):6682-6691. doi: 10.1021/acs.jafc.7b02280. Epub 2017 Jul 27. PubMed PMID: 28699743.
5: López-García M, Romero-González R, Frenich AG. Determination of rodenticides and related metabolites in rabbit liver and biological matrices by liquid chromatography coupled to Orbitrap high resolution mass spectrometry. J Pharm Biomed Anal. 2017 Apr 15;137:235-242. doi: 10.1016/j.jpba.2017.01.043. Epub 2017 Jan 28. PubMed PMID: 28160742.
6: Hsu CW, Hsieh JH, Huang R, Pijnenburg D, Khuc T, Hamm J, Zhao J, Lynch C, van Beuningen R, Chang X, Houtman R, Xia M. Differential modulation of FXR activity by chlorophacinone and ivermectin analogs. Toxicol Appl Pharmacol. 2016 Dec 15;313:138-148. doi: 10.1016/j.taap.2016.10.017. Epub 2016 Oct 20. PubMed PMID: 27773686; PubMed Central PMCID: PMC5124510.
7: Saito-Shida S, Nemoto S, Matsuda R, Akiyama H. Simultaneous determination of seven anticoagulant rodenticides in agricultural products by gel permeation chromatography and liquid chromatography-tandem mass spectrometry. J Environ Sci Health B. 2016 Nov;51(11):801-8. doi: 10.1080/03601234.2016.1198654. Epub 2016 Jul 18. PubMed PMID: 27428755.
8: Maršálek P, Modrá H, Doubková V, Večerek V. Simultaneous determination of ten anticoagulant rodenticides in tissues by column-switching UHPLC-ESI-MS/MS. Anal Bioanal Chem. 2015 Oct;407(25):7849-54. doi: 10.1007/s00216-015-8954-1. Epub 2015 Aug 18. PubMed PMID: 26280206.
9: Witmer GW, Snow NP, Moulton RS. Retention time of chlorophacinone in black-tailed prairie dogs informs secondary hazards from a prairie dog rodenticide bait. Pest Manag Sci. 2016 Apr;72(4):725-30. doi: 10.1002/ps.4045. Epub 2015 Jun 18. PubMed PMID: 25997570.
10: Rattner BA, Horak KE, Lazarus RS, Schultz SL, Knowles S, Abbo BG, Volker SF. Toxicity reference values for chlorophacinone and their application for assessing anticoagulant rodenticide risk to raptors. Ecotoxicology. 2015 May;24(4):720-34. doi: 10.1007/s10646-015-1418-8. Epub 2015 Jan 20. PubMed PMID: 25600128.
11: Bidny S, Gago K, David M, Duong T, Albertyn D, Gunja N. A validated LC-MS-MS method for simultaneous identification and quantitation of rodenticides in blood. J Anal Toxicol. 2015 Apr;39(3):219-24. doi: 10.1093/jat/bku175. Epub 2015 Jan 16. PubMed PMID: 25595137.
12: Esther A, Endepols S, Freise J, Klemann N, Runge M, Pelz HJ. [Rodenticide resistance and consequences]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 May;57(5):519-23. doi: 10.1007/s00103-013-1930-z. German. PubMed PMID: 24781908.
13: Baldwin RA, Quinn N, Davis DH, Engeman RM. Effectiveness of rodenticides for managing invasive roof rats and native deer mice in orchards. Environ Sci Pollut Res Int. 2014 May;21(9):5795-802. doi: 10.1007/s11356-014-2525-4. Epub 2014 Jan 19. PubMed PMID: 24443051.
14: Hernández AM, Bernal J, Bernal JL, Martín MT, Caminero C, Nozal MJ. Simultaneous determination of nine anticoagulant rodenticides in soil and water by LC-ESI-MS. J Sep Sci. 2013 Aug;36(16):2593-601. doi: 10.1002/jssc.201300310. Epub 2013 Jul 11. PubMed PMID: 23733735.
15: Rutović S, Dikanović M, Mirković I, Lojen G, Marcikić M. Intracerebellar hemorrhage caused by superwarfarin poisoning. Neurol Sci. 2013 Nov;34(11):2071-2. doi: 10.1007/s10072-013-1445-2. Epub 2013 Apr 18. PubMed PMID: 23595548.
16: Hernández AM, Bernal J, Bernal JL, Martín MT, Caminero C, Nozal MJ. Analysis of anticoagulant rodenticide residues in Microtus arvalis tissues by liquid chromatography with diode array, fluorescence and mass spectrometry detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Apr 15;925:76-85. doi: 10.1016/j.jchromb.2013.02.032. Epub 2013 Mar 4. PubMed PMID: 23523881.
17: Waddell LS, Poppenga RH, Drobatz KJ. Anticoagulant rodenticide screening in dogs: 123 cases (1996-2003). J Am Vet Med Assoc. 2013 Feb 15;242(4):516-21. doi: 10.2460/javma.242.4.516. PubMed PMID: 23363284.
18: Vein J, Vey D, Fourel I, Berny P. Bioaccumulation of chlorophacinone in strains of rats resistant to anticoagulants. Pest Manag Sci. 2013 Mar;69(3):397-402. doi: 10.1002/ps.3367. Epub 2012 Oct 29. PubMed PMID: 23109180.
19: Vyas NB, Hulse CS, Rice CP. Chlorophacinone residues in mammalian prey at a black-tailed prairie dog colony. Environ Toxicol Chem. 2012 Nov;31(11):2513-6. doi: 10.1002/etc.1968. Epub 2012 Sep 7. PubMed PMID: 22865654.
20: Buckle A. Anticoagulant resistance in the United Kingdom and a new guideline for the management of resistant infestations of Norway rats (Rattus norvegicus Berk.). Pest Manag Sci. 2013 Mar;69(3):334-41. doi: 10.1002/ps.3309. Epub 2012 Jun 25. Review. PubMed PMID: 22730379.
