L 693989

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H596655

CAS#: 138661-20-8

Description: L 693989 is a pneumocandin.

Chemical Structure

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L 693989
CAS# 138661-20-8
Instruction

Theoretical Analysis

Hodoodo Cat#: H596655
Name: L 693989
CAS#: 138661-20-8
Chemical Formula: C50H80N8NaO20P
Exact Mass: 1,166.51
Molecular Weight: 1,167.180
Elemental Analysis: C, 51.45; H, 6.91; N, 9.60; Na, 1.97; O, 27.41; P, 2.65

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L 693989; L-693989; L693989; L-693,989; L 693,989; L693,989;

IUPAC/Chemical Name: sodium 4-((1S,2R)-2-((2S,6R,9R,11S,12S,14aR,15R,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-9-((10R,12S)-10,12-dimethyltetradecanamido)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)phenyl hydrogen phosphate

InChi Key: VAHIZUPRWJROTF-RBKNGNFHSA-M

InChi Code: InChI=1S/C50H81N8O20P.Na/c1-5-25(2)20-26(3)12-10-8-6-7-9-11-13-37(65)52-31-22-35(63)46(70)56-48(72)41-33(61)18-19-57(41)50(74)39(34(62)23-36(51)64)54-47(71)40(43(67)42(66)28-14-16-30(17-15-28)78-79(75,76)77)55-45(69)32-21-29(60)24-58(32)49(73)38(27(4)59)53-44(31)68;/h14-17,25-27,29,31-35,38-43,46,59-63,66-67,70H,5-13,18-24H2,1-4H3,(H2,51,64)(H,52,65)(H,53,68)(H,54,71)(H,55,69)(H,56,72)(H2,75,76,77);/q;+1/p-1/t25-,26+,27+,29-,31+,32-,33+,34+,35-,38+,39-,40-,41+,42-,43+,46-;/m0./s1

SMILES Code: O[C@H]1C[C@@H](C(N[C@H](C(N[C@H](C(N2CC[C@H]([C@@H]2C(N[C@H]([C@H](C[C@H](C(N[C@H]([C@H](O)C)C3=O)=O)NC(CCCCCCCC[C@H](C[C@H](CC)C)C)=O)O)O)=O)O)=O)[C@H](O)CC(N)=O)=O)[C@H]([C@H](c4ccc(OP([O-])(O)=O)cc4)O)O)=O)N3C1.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,167.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Flattery AM, Abruzzo GK, Gill CJ, Smith JG, Bartizal K. New model of oropharyngeal and gastrointestinal colonization by Candida albicans in CD4+ T-cell-deficient mice for evaluation of antifungal agents. Antimicrob Agents Chemother. 1996 Jul;40(7):1604-9. PubMed PMID: 8807048; PubMed Central PMCID: PMC163381.

2: Kurtz MB, Bernard EM, Edwards FF, Marrinan JA, Dropinski J, Douglas CM, Armstrong D. Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis. Antimicrob Agents Chemother. 1995 Aug;39(8):1784-9. PubMed PMID: 7486919; PubMed Central PMCID: PMC162826.

3: Schmatz DM, Powles MA, McFadden D, Nollstadt K, Bouffard FA, Dropinski JF, Liberator P, Andersen J. New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat. Antimicrob Agents Chemother. 1995 Jun;39(6):1320-3. PubMed PMID: 7574523; PubMed Central PMCID: PMC162734.

4: Powles MA, McFadden DC, Liberator PA, Anderson JW, Vadas EB, Meisner D, Schmatz DM. Aerosolized L-693,989 for Pneumocystis carinii prophylaxis in rats. Antimicrob Agents Chemother. 1994 Jun;38(6):1397-401. PubMed PMID: 8092844; PubMed Central PMCID: PMC188217.

5: Schmatz DM, Powles MA, McFadden DC, Pittarelli L, Balkovec J, Hammond M, Zambias R, Liberator P, Anderson J. Antipneumocystis activity of water-soluble lipopeptide L-693,989 in rats. Antimicrob Agents Chemother. 1992 Sep;36(9):1964-70. PubMed PMID: 1416888; PubMed Central PMCID: PMC192216.