WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H596662
CAS#: 150461-07-7
Description: L 691816 is a potent inhibitor of the 5-LO reaction both in vitro and in a range of in vivo models.
Hodoodo Cat#: H596662
Name: L 691816
CAS#: 150461-07-7
Chemical Formula: C36H35ClN6OS
Exact Mass: 634.23
Molecular Weight: 635.220
Elemental Analysis: C, 68.07; H, 5.55; Cl, 5.58; N, 13.23; O, 2.52; S, 5.05
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Synonym: L 691816; L-691816; L691816; L-691,816; L 691,816; L691,816;
IUPAC/Chemical Name: 1-(4-chlorobenzyl)-2-(2,2-dimethyl-3-(1H-tetrazol-5-yl)propyl)-4-methyl-6-((5-phenylpyridin-2-yl)methoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indole
InChi Key: ZXTQNTHPGKKAHX-UHFFFAOYSA-N
InChi Code: InChI=1S/C36H35ClN6OS/c1-23-17-29-32(44-22-28-14-11-26(20-38-28)25-7-5-4-6-8-25)16-15-30-34(29)35(45-23)31(18-36(2,3)19-33-39-41-42-40-33)43(30)21-24-9-12-27(37)13-10-24/h4-16,20,23H,17-19,21-22H2,1-3H3,(H,39,40,41,42)
SMILES Code: CC(CC(N1CC2=CC=C(Cl)C=C2)=C3C4=C1C=CC(OCC5=NC=C(C6=CC=CC=C6)C=C5)=C4CC(C)S3)(C)CC7=NN=NN7
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 635.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Hutchinson JH, Riendeau D, Brideau C, Chan C, Delorme D, Denis D, Falgueyret JP, Fortin R, Guay J, Hamel P, et al. Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816. J Med Chem. 1993 Sep 17;36(19):2771-87. PubMed PMID: 8410991.