MDM2-p53-IN-1b

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H562947

CAS#: 856435-40-0

Description: MDM2-p53-IN-1b is an inhibitor of the MDM2-p53 interaction.

Chemical Structure

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MDM2-p53-IN-1b
CAS# 856435-40-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H562947
Name: MDM2-p53-IN-1b
CAS#: 856435-40-0
Chemical Formula: C17H15NO3
Exact Mass: 281.11
Molecular Weight: 281.310
Elemental Analysis: C, 72.58; H, 5.37; N, 4.98; O, 17.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MDM2-p53-IN-1b; MDM2 p53 IN 1b; MDM2p53IN1b; MDM2-p53 inhibitor 1b;

IUPAC/Chemical Name: (3E)-3-[(2,4-dimethoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one

InChi Key: PSRHWNITWXEJJW-NTEUORMPSA-N

InChi Code: InChI=1S/C17H15NO3/c1-20-12-8-7-11(16(10-12)21-2)9-14-13-5-3-4-6-15(13)18-17(14)19/h3-10H,1-2H3,(H,18,19)/b14-9+

SMILES Code: O=C1NC2=C(C=CC=C2)/C1=C\C3=CC=C(OC)C=C3OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 281.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Boyarskikh UA, Shadrina AS, Smetanina MA, Tsepilov YA, Oscorbin IP, Kozlov VV, Kel AE, Filipenko ML. Mycoplasma hyorhinis reduces sensitivity of human lung carcinoma cells to Nutlin-3 and promotes their malignant phenotype. J Cancer Res Clin Oncol. 2018 May 8. doi: 10.1007/s00432-018-2658-9. [Epub ahead of print] PubMed PMID: 29737431.

2: Uesato S, Matsuura Y, Matsue S, Sumiyoshi T, Hirata Y, Takemoto S, Kawaratani Y, Yamai Y, Ishida K, Sasaki T, Enari M. Discovery of new low-molecular-weight p53-Mdmx disruptors and their anti-cancer activities. Bioorg Med Chem. 2016 Apr 15;24(8):1919-26. doi: 10.1016/j.bmc.2016.03.021. Epub 2016 Mar 11. PubMed PMID: 27010502.

3: Hailfinger S, Jaworski M, Marx-Stoelting P, Wanke I, Schwarz M. Regulation of P53 stability in p53 mutated human and mouse hepatoma cells. Int J Cancer. 2007 Apr 1;120(7):1459-64. PubMed PMID: 17205518.