WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H596780
CAS#: 210355-14-9
Description: QYL-685 is a methylenecyclopropane nucleoside analogue with a phenylphosphoralaninate moiety.
Hodoodo Cat#: H596780
Name: QYL-685
CAS#: 210355-14-9
Chemical Formula: C20H24N7O5P
Exact Mass: 473.16
Molecular Weight: 473.420
Elemental Analysis: C, 50.74; H, 5.11; N, 20.71; O, 16.90; P, 6.54
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Synonym: QYL-685; QYL 685; QYL685;
IUPAC/Chemical Name: methyl ((((Z)-2-((2,6-diamino-9H-purin-9-yl)methylene)cyclopropyl)methoxy)(phenoxy)phosphoryl)-L-alaninate
InChi Key: XHUFBJWIETZGNX-QUADACEYSA-N
InChi Code: InChI=1S/C20H24N7O5P/c1-12(19(28)30-2)26-33(29,32-15-6-4-3-5-7-15)31-10-14-8-13(14)9-27-11-23-16-17(21)24-20(22)25-18(16)27/h3-7,9,11-12,14H,8,10H2,1-2H3,(H,26,29)(H4,21,22,24,25)/b13-9-/t12-,14?,33?/m0/s1
SMILES Code: C[C@@H](C(OC)=O)NP(OC1=CC=CC=C1)(OCC2/C(C2)=C\N3C=NC4=C(N)N=C(N)N=C34)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 473.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Yoshimura K, Feldman R, Kodama E, Kavlick MF, Qiu YL, Zemlicka J, Mitsuya H. In vitro induction of human immunodeficiency virus type 1 variants resistant to phosphoralaninate prodrugs of Z-methylenecyclopropane nucleoside analogues. Antimicrob Agents Chemother. 1999 Oct;43(10):2479-83. PubMed PMID: 10508028; PubMed Central PMCID: PMC89504.
2: Uchida H, Kodama EN, Yoshimura K, Maeda Y, Kosalaraksa P, Maroun V, Qiu YL, Zemlicka J, Mitsuya H. In vitro anti-human immunodeficiency virus activities of Z- and E-methylenecyclopropane nucleoside analogues and their phosphoro-L-alaninate diesters. Antimicrob Agents Chemother. 1999 Jun;43(6):1487-90. PubMed PMID: 10348777; PubMed Central PMCID: PMC89303.