WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H596820
CAS#: 1397-85-9
Description: Alazopeptin monohydrate is a microbial metabolite. Alazopeptin is an antibiotic, with moderate anti-trypanosomal. and antitumor activity. It was originally isolated from Streptomyces griseoplanus, sourced from soil near Williamsburg, Iowa. It is still largely produced via fermentation broths of that organism.
Hodoodo Cat#: H596820
Name: Alazopeptin monohydrate
CAS#: 1397-85-9
Chemical Formula: C15H22N6O6
Exact Mass: 0.00
Molecular Weight: 382.370
Elemental Analysis: C, 47.12; H, 5.80; N, 21.98; O, 25.10
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Synonym: Alazopeptin monohydrate;
IUPAC/Chemical Name: (S)-2-((S)-N-allyl-2-amino-6-diazo-5-oxohexanamido)-6-diazo-5-oxohexanoic acid hydrate
InChi Key: RQTGOFHXECVMJM-QNTKWALQSA-N
InChi Code: InChI=1S/C15H20N6O5.H2O/c1-2-7-21(13(15(25)26)6-4-11(23)9-20-18)14(24)12(16)5-3-10(22)8-19-17;/h2,8-9,12-13H,1,3-7,16H2,(H,25,26);1H2/t12-,13-;/m0./s1
SMILES Code: O=C(O)[C@H](CCC(C=[N+]=[N-])=O)N(CC=C)C([C@H](CCC(C=[N+]=[N-])=O)N)=O.[H]O[H]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 382.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Ishiyama A, Otoguro K, Namatame M, Nishihara A, Furusawa T, Masuma R, Shiomi K, Takahashi Y, Ichimura M, Yamada H, Omura S. In vitro and in vivo antitrypanosomal activitiy of two microbial metabolites, KS-505a and alazopeptin. J Antibiot (Tokyo). 2008 Oct;61(10):627-32. doi: 10.1038/ja.2008.83. PubMed PMID: 19168977.
2: Hata T, Umezawa I, Iwai Y, Katagiri M, Awaya J. Studies on the antitumor activity of an alazopeptin isolated from a new strain of Streptomyces. J Antibiot (Tokyo). 1973 Mar;26(3):181-3. PubMed PMID: 4205875.
3: Patterson EL, Johnson BL, DeVoe SE, Bohonos N. Structure of the antitumor antibiotic alazopeptin. Antimicrob Agents Chemother (Bethesda). 1965;5:115-8. PubMed PMID: 5883414.
4: THIERSCH JB. Effect of alazopeptin on litter and fetus of the rat in utero. Proc Soc Exp Biol Med. 1958 Apr;97(4):888-9. PubMed PMID: 13554513.
5: DE VOE SE, RIGLER NE, SHAY AJ, MARTIN JH, BOYD TC, BACKUS EJ, MOWAT JH, BOHONOS N. Alazopeptin; production, isolation, and chemical characteristics. Antibiot Annu. 1956-1957:730-5. PubMed PMID: 13425456.
