Amb123203

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H563023

CAS#: 956571-77-0

Description: Amb123203 is an inhibitor of budding of mVP40 and eVP40 VLPs. It acts by blocking mVP40-795 Nedd4 protein-protein interaction.

Chemical Structure

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Amb123203
CAS# 956571-77-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H563023
Name: Amb123203
CAS#: 956571-77-0
Chemical Formula: C25H27N5OS
Exact Mass: 445.19
Molecular Weight: 445.580
Elemental Analysis: C, 67.39; H, 6.11; N, 15.72; O, 3.59; S, 7.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Amb123203; Amb-123203; Amb 123203; PPxY Budding Inhibitor 4;

IUPAC/Chemical Name: 3-(2-Benzothiazolyl)-N-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)-1-piperidineacetamide

InChi Key: JKGGFVABTBFVOC-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H27N5OS/c1-17-24(18(2)30(28-17)20-10-4-3-5-11-20)27-23(31)16-29-14-8-9-19(15-29)25-26-21-12-6-7-13-22(21)32-25/h3-7,10-13,19H,8-9,14-16H2,1-2H3,(H,27,31)

SMILES Code: O=C(NC1=C(C)N(C2=CC=CC=C2)N=C1C)CN3CC(C4=NC5=CC=CC=C5S4)CCC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 445.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Han Z, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Harty RN. ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding. J Virol. 2016 Sep 29;90(20):9163-71. doi: 10.1128/JVI.01078-16. Print 2016 Oct 15. PubMed PMID: 27489272; PubMed Central PMCID: PMC5044852.