WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H558178
CAS#: 63811-80-3
Description: KBG 4 is a bioactive chemical.
Hodoodo Cat#: H558178
Name: KBG 4
CAS#: 63811-80-3
Chemical Formula: C14H29O2PS2
Exact Mass: 324.13
Molecular Weight: 324.480
Elemental Analysis: C, 51.82; H, 9.01; O, 9.86; P, 9.55; S, 19.76
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: KBG 4;
IUPAC/Chemical Name: Phosphonothioic acid, cyclohexyl-, S-(2-(butylthio)ethyl) O-ethyl ester
InChi Key: YWRVQYRJLKWEGX-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H29O2PS2/c1-3-5-11-18-12-13-19-17(15,16-4-2)14-9-7-6-8-10-14/h14H,3-13H2,1-2H3
SMILES Code: O=P(C1CCCCC1)(SCCSCCCC)OCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 324.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Khalifa M, Stein J, Grau L, Nelson V, Meck J, Aradhya S, Duby J. Partial deletion of ANKRD11 results in the KBG phenotype distinct from the 16q24.3 microdeletion syndrome. Am J Med Genet A. 2013 Apr;161A(4):835-40. doi: 10.1002/ajmg.a.35739. Epub 2013 Mar 12. PubMed PMID: 23494856.
2: Samanta D, Willis E. Electroencephalographic findings in KBG syndrome: a child with novel mutation in ANKRD11 gene. Acta Neurol Belg. 2015 Dec;115(4):779-82. doi: 10.1007/s13760-014-0413-9. Epub 2014 Dec 28. PubMed PMID: 25543316.
3: Parenti I, Gervasini C, Pozojevic J, Graul-Neumann L, Azzollini J, Braunholz D, Watrin E, Wendt KS, Cereda A, Cittaro D, Gillessen-Kaesbach G, Lazarevic D, Mariani M, Russo S, Werner R, Krawitz P, Larizza L, Selicorni A, Kaiser FJ. Broadening of cohesinopathies: exome sequencing identifies mutations in ANKRD11 in two patients with Cornelia de Lange-overlapping phenotype. Clin Genet. 2016 Jan;89(1):74-81. doi: 10.1111/cge.12564. Epub 2015 Feb 25. PubMed PMID: 25652421.
4: Mizawa M, Makino T, Hikiami H, Shimada Y, Shimizu T. Effectiveness of keishibukuryogan on chronic-stage lichenification associated with atopic dermatitis. ISRN Dermatol. 2012;2012:158598. doi: 10.5402/2012/158598. Epub 2012 Nov 14. PubMed PMID: 23213558; PubMed Central PMCID: PMC3504367.
5: Mori T, Sakamoto S, Singtripop T, Park MK, Kato T, Kawashima S, Nagasawa H. Suppression of spontaneous development of uterine adenomyosis by a Chinese herbal medicine, keishi-bukuryo-gan, in mice. Planta Med. 1993 Aug;59(4):308-11. PubMed PMID: 8372144.
6: Norisugi O, Yoshihisa Y, Shimizu K, Shimizu T. In vitro cytokine expression by peripheral mononuclear cells in herbal drug-induced skin eruption. Acta Derm Venereol. 2014 Jan;94(1):58-62. doi: 10.2340/00015555-1631. PubMed PMID: 23817527.
7: Nagata Y, Goto H, Hikiami H, Nogami T, Fujimoto M, Shibahara N, Shimada Y. Effect of keishibukuryogan on endothelial function in patients with at least one component of the diagnostic criteria for metabolic syndrome: a controlled clinical trial with crossover design. Evid Based Complement Alternat Med. 2012;2012:359282. doi: 10.1155/2012/359282. Epub 2012 May 22. PubMed PMID: 22675380; PubMed Central PMCID: PMC3364603.
8: Soekarman D, Volcke P, Fryns JP. The KBG syndrome: follow-up data on three affected brothers. Clin Genet. 1994 Oct;46(4):283-6. PubMed PMID: 7834892.
9: Hikiami H, Goto H, Sekiya N, Hattori N, Sakakibara I, Shimada Y, Terasawa K. Comparative efficacy of Keishi-bukuryo-gan and pentoxifylline on RBC deformability in patients with "oketsu" syndrome. Phytomedicine. 2003;10(6-7):459-66. PubMed PMID: 13678228.
10: Rivera-Vega MR, Leyva Juárez N, Cuevas-Covarrubias SA, Kofman-Alfaro SH. Congenital heart defect and conductive hypoacusia in a patient with the KBG syndrome. Clin Genet. 1996 Oct;50(4):278-9. PubMed PMID: 9001820.
11: Sekiya N, Goto H, Shimada Y, Terasawa K. Inhibitory effects of Keishi-bukuryo-gan on free radical induced lysis of rat red blood cells. Phytother Res. 2002 Jun;16(4):373-6. PubMed PMID: 12112296.
12: Sekiya N, Goto H, Tazawa K, Oida S, Shimada Y, Terasawa K. Keishi-bukuryo-gan preserves the endothelium dependent relaxation of thoracic aorta in cholesterol-fed rabbit by limiting superoxide generation. Phytother Res. 2002 Sep;16(6):524-8. PubMed PMID: 12237808.
13: Ansari M, Poke G, Ferry Q, Williamson K, Aldridge R, Meynert AM, Bengani H, Chan CY, Kayserili H, Avci S, Hennekam RC, Lampe AK, Redeker E, Homfray T, Ross A, Falkenberg Smeland M, Mansour S, Parker MJ, Cook JA, Splitt M, Fisher RB, Fryer A, Magee AC, Wilkie A, Barnicoat A, Brady AF, Cooper NS, Mercer C, Deshpande C, Bennett CP, Pilz DT, Ruddy D, Cilliers D, Johnson DS, Josifova D, Rosser E, Thompson EM, Wakeling E, Kinning E, Stewart F, Flinter F, Girisha KM, Cox H, Firth HV, Kingston H, Wee JS, Hurst JA, Clayton-Smith J, Tolmie J, Vogt J, Tatton-Brown K, Chandler K, Prescott K, Wilson L, Behnam M, McEntagart M, Davidson R, Lynch SA, Sisodiya S, Mehta SG, McKee SA, Mohammed S, Holden S, Park SM, Holder SE, Harrison V, McConnell V, Lam WK, Green AJ, Donnai D, Bitner-Glindzicz M, Donnelly DE, Nellåker C, Taylor MS, FitzPatrick DR. Genetic heterogeneity in Cornelia de Lange syndrome (CdLS) and CdLS-like phenotypes with observed and predicted levels of mosaicism. J Med Genet. 2014 Oct;51(10):659-68. doi: 10.1136/jmedgenet-2014-102573. Epub 2014 Aug 14. PubMed PMID: 25125236; PubMed Central PMCID: PMC4173748.
14: Ekramoddoullah AK, Kisil FT, Sehon AH. Isolation of allergenically active cytochrome c from Kentucky blue grass pollen. Int Arch Allergy Appl Immunol. 1981;65(4):367-76. PubMed PMID: 6265378.
15: Spengler S, Oehl-Jaschkowitz B, Begemann M, Hennes P, Zerres K, Eggermann T. Haploinsufficiency of ANKRD11 (16q24.3) Is Not Obligatorily Associated with Cognitive Impairment but Shows a Clinical Overlap with Silver-Russell Syndrome. Mol Syndromol. 2013 Jun;4(5):246-9. doi: 10.1159/000351765. Epub 2013 Jun 8. PubMed PMID: 23885231; PubMed Central PMCID: PMC3711485.
16: Mohapatra SS, Hill R, Astwood J, Ekramoddoullah AK, Olsen E, Silvanovitch A, Hatton T, Kisil FT, Sehon AH. Isolation and characterization of a cDNA clone encoding an IgE-binding protein from Kentucky bluegrass (Poa pratensis) pollen. Int Arch Allergy Appl Immunol. 1990;91(4):362-8. PubMed PMID: 2210872.
17: Matsumoto C, Kojima T, Ogawa K, Kamegai S, Oyama T, Shibagaki Y, Kawasaki T, Fujinaga H, Takahashi K, Hikiami H, Goto H, Kiga C, Koizumi K, Sakurai H, Muramoto H, Shimada Y, Yamamoto M, Terasawa K, Takeda S, Saiki I. A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine. Evid Based Complement Alternat Med. 2008 Dec;5(4):463-74. doi: 10.1093/ecam/nem049. Epub 2007 Jun 15. PubMed PMID: 18955217; PubMed Central PMCID: PMC2586309.
18: Filippi G. Unusual facial appearance, microcephaly, growth and mental retardation, and syndactyly. A new syndrome? Am J Med Genet. 1985 Dec;22(4):821-4. PubMed PMID: 4073130.
19: Ekramoddoullah AK, Chakrabarty S, Kisil FT, Sehon AH. Isolation of a purified allergen from Kentucky blue grass pollen. Int Arch Allergy Appl Immunol. 1980;63(2):220-35. PubMed PMID: 7419287.
20: Chakrabarty S, Ekramoddoullah AK, Kisil FT, Sehon AH. Allergens of Kentucky Blue Grass pollen. II. Isolation of hapten-like components from Kentucky Blue Grass pollen by preparative isoelectrofocussing. Int Arch Allergy Appl Immunol. 1980;63(4):369-82. PubMed PMID: 7429651.