WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H558201
CAS#: 177742-52-8
Description: Keenamide A is a cytotoxic cyclic hexapeptide and exhibits significant activity against the P-388, A-549, MEL-20, and HT-29 tumor cell lines, but was inactive when evaluated against the D6 and W2 Plasmodium falciparum malarial clones.
Hodoodo Cat#: H558201
Name: Keenamide A
CAS#: 177742-52-8
Chemical Formula: C30H48N6O6S
Exact Mass: 620.34
Molecular Weight: 620.810
Elemental Analysis: C, 58.04; H, 7.79; N, 13.54; O, 15.46; S, 5.16
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Synonym: Keenamide A;
IUPAC/Chemical Name: (2S,3S)-1-((2R,3S)-2,3-diamino-2-((2S,3R)-4-(4,5-dihydrothiazol-2-yl)-3-methyl-4-oxobutan-2-yl)-5-methylhexanoyl)-3-(2-iminoacetyl)-2-(O-(2-methylbut-3-en-2-yl)-L-seryl)pyrrolidine-2-carbaldehyde
InChi Key: ZPUJRWJSNBAKEH-YDCOKLBLSA-N
InChi Code: InChI=1S/C30H48N6O6S/c1-8-28(6,7)42-15-21(32)25(40)29(16-37)20(22(38)14-31)9-11-36(29)27(41)30(34,23(33)13-17(2)3)19(5)18(4)24(39)26-35-10-12-43-26/h8,14,16-21,23,31H,1,9-13,15,32-34H2,2-7H3/t18-,19+,20-,21+,23+,29-,30-/m1/s1
SMILES Code: N=CC([C@H]1CCN(C([C@@]([C@@H](C)[C@H](C(C2=NCCS2)=O)C)([C@@H](N)CC(C)C)N)=O)[C@]1(C([C@H](COC(C)(C)C=C)N)=O)C=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 620.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Wesson KJ, Hamann MT. Keenamide A, a bioactive cyclic peptide from the marine mollusk Pleurobranchus forskalii. J Nat Prod. 1996 Jun;59(6):629-31. PubMed PMID: 8786369.
2: Donia MS, Wang B, Dunbar DC, Desai PV, Patny A, Avery M, Hamann MT. Mollamides B and C, Cyclic hexapeptides from the indonesian tunicate Didemnum molle. J Nat Prod. 2008 Jun;71(6):941-5. doi: 10.1021/np700718p. Epub 2008 Jun 11. PubMed PMID: 18543965; PubMed Central PMCID: PMC2651694.