Monobutyl phthalate
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H591750

CAS#: 131-70-4

Description: Monobutyl phthalate affects the expressions of EMT-related proteins and enhances the migration and invasion of MLTC-1 cells.

Chemical Structure

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Monobutyl phthalate
CAS# 131-70-4
Instruction

Theoretical Analysis

Hodoodo Cat#: H591750
Name: Monobutyl phthalate
CAS#: 131-70-4
Chemical Formula: C12H14O4
Exact Mass: 222.09
Molecular Weight: 222.240
Elemental Analysis: C, 64.85; H, 6.35; O, 28.80

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Synonym: Monobutyl phthalate; NSC 8479; NSC-8479; NSC8479

IUPAC/Chemical Name: 1,2-Benzenedicarboxylic acid, 1-butyl ester

InChi Key: YZBOVSFWWNVKRJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H14O4/c1-2-3-8-16-12(15)10-7-5-4-6-9(10)11(13)14/h4-7H,2-3,8H2,1H3,(H,13,14)

SMILES Code: O=C(C1=CC=CC=C1C(O)=O)OCCCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 222.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cheng J, Liu Y, Wan Q, Yuan L, Yu X. Degradation of dibutyl phthalate in two contrasting agricultural soils and its long-term effects on soil microbial community. Sci Total Environ. 2018 Jun 4;640-641:821-829. doi: 10.1016/j.scitotenv.2018.05.336. [Epub ahead of print] PubMed PMID: 29879668.

2: Gong P, Lu HC, Zhang C, Chen SS, Wang YB. [Effects of monobutyl phthalate on migration and invasion of mouse Leydig tumor cells]. Zhonghua Yu Fang Yi Xue Za Zhi. 2018 Feb 6;52(2):175-179. doi: 10.3760/cma.j.issn.0253-9624.2018.02.011. Chinese. PubMed PMID: 29429273.

3: Wenzel AG, Brock JW, Cruze L, Newman RB, Unal ER, Wolf BJ, Somerville SE, Kucklick JR. Prevalence and predictors of phthalate exposure in pregnant women in Charleston, SC. Chemosphere. 2018 Feb;193:394-402. doi: 10.1016/j.chemosphere.2017.11.019. Epub 2017 Nov 8. PubMed PMID: 29154114.

4: Huang HB, Chuang CJ, Su PH, Sun CW, Wang CJ, Wu MT, Wang SL. Prenatal and Childhood Exposure to Phthalate Diesters and Thyroid Function in a 9-Year Follow-up Birth Cohort Study: Taiwan Maternal and Infant Cohort Study. Epidemiology. 2017 Oct;28 Suppl 1:S10-S18. doi: 10.1097/EDE.0000000000000722. PubMed PMID: 29028671.

5: Yang P, Gong YJ, Wang YX, Liang XX, Liu Q, Liu C, Chen YJ, Sun L, Lu WQ, Zeng Q. Effect modification by apoptosis-related gene polymorphisms on the associations of phthalate exposure with spermatozoa apoptosis and semen quality. Environ Pollut. 2017 Dec;231(Pt 1):694-702. doi: 10.1016/j.envpol.2017.08.034. Epub 2017 Aug 29. PubMed PMID: 28850937.

6: Kurohane K, Sekiguchi K, Ogawa E, Tsutsumi M, Imai Y. Dibutyl Phthalate Rather than Monobutyl Phthalate Facilitates Contact Hypersensitivity to Fluorescein Isothiocyanate in a Mouse Model. Biol Pharm Bull. 2017 Nov 1;40(11):2010-2013. doi: 10.1248/bpb.b17-00557. Epub 2017 Aug 26. PubMed PMID: 28845027.

7: Saengkaew T, Jantarat C, Nosoognoen W, Supornsilchai V. Association between urinary phthalates and metabolic abnormalities in obese Thai children and adolescents. J Pediatr Endocrinol Metab. 2017 Aug 28;30(9):931-938. doi: 10.1515/jpem-2017-0172. PubMed PMID: 28771440.

8: Gao H, Zhang YW, Huang K, Yan SQ, Mao LJ, Ge X, Xu YQ, Xu YY, Sheng J, Jin ZX, Zhu P, Tao XG, Hao JH, Tao FB. Urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women. Sci Rep. 2017 Jul 28;7(1):6800. doi: 10.1038/s41598-017-06450-2. PubMed PMID: 28754983; PubMed Central PMCID: PMC5533765.

9: Zhang C, Gong P, Ye Y, Zhang L, Chen M, Hu Y, Gu A, Chen S, Wang Y. NF-κB-vimentin is involved in steroidogenesis stimulated by mono-butyl phthalate in primary cultured ovarian granulosa cells. Toxicol In Vitro. 2017 Dec;45(Pt 1):25-30. doi: 10.1016/j.tiv.2017.07.012. Epub 2017 Jul 19. PubMed PMID: 28735033.

10: Moreau M, Leonard J, Phillips KA, Campbell J, Pendse SN, Nicolas C, Phillips M, Yoon M, Tan YM, Smith S, Pudukodu H, Isaacs K, Clewell H. Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates. Chemosphere. 2017 Oct;184:1194-1201. doi: 10.1016/j.chemosphere.2017.06.098. Epub 2017 Jun 24. PubMed PMID: 28672700.

11: Kumar V, Sharma N, Maitra SS. Comparative study on the degradation of dibutyl phthalate by two newly isolated Pseudomonas sp. V21b and Comamonas sp. 51F. Biotechnol Rep (Amst). 2017 Apr 28;15:1-10. doi: 10.1016/j.btre.2017.04.002. eCollection 2017 Sep. PubMed PMID: 28580302; PubMed Central PMCID: PMC5447571.

12: Sugino M, Hatanaka T, Todo H, Mashimo Y, Suzuki T, Kobayashi M, Hosoya O, Jinno H, Juni K, Sugibayashi K. Safety evaluation of dermal exposure to phthalates: Metabolism-dependent percutaneous absorption. Toxicol Appl Pharmacol. 2017 Aug 1;328:10-17. doi: 10.1016/j.taap.2017.05.009. Epub 2017 May 12. PubMed PMID: 28506834.

13: Du J, Xiong D, Zhang Q, Li X, Liu X, You H, Ding S, Yang X, Yuan J. Mono-butyl phthalate-induced mouse testis injury is associated with oxidative stress and down-regulated expression of Sox9 and Dazl. J Toxicol Sci. 2017;42(3):319-328. doi: 10.2131/jts.42.319. PubMed PMID: 28496037.

14: Gao H, Zhu YD, Xu YY, Zhang YW, Yao HY, Sheng J, Jin ZX, Ren LL, Huang K, Hao JH, Tao FB. Season-dependent concentrations of urinary phthalate metabolites among Chinese pregnant women: Repeated measures analysis. Environ Int. 2017 Jul;104:110-117. doi: 10.1016/j.envint.2017.03.021. Epub 2017 Apr 4. PubMed PMID: 28389128.

15: Wang IJ, Karmaus WJ. Oxidative Stress-Related Genetic Variants May Modify Associations of Phthalate Exposures with Asthma. Int J Environ Res Public Health. 2017 Feb 8;14(2). pii: E162. doi: 10.3390/ijerph14020162. PubMed PMID: 28208751; PubMed Central PMCID: PMC5334716.

16: Thomsen AM, Riis AH, Olsen J, Jönsson BA, Lindh CH, Hjollund NH, Jensen TK, Bonde JP, Toft G. Female exposure to phthalates and time to pregnancy: a first pregnancy planner study. Hum Reprod. 2017 Jan;32(1):232-238. Epub 2016 Nov 16. PubMed PMID: 27852689.

17: Lin Q, Chen S, Chao Y, Huang X, Wang S, Qiu R. Carboxylesterase-involved metabolism of di-n-butyl phthalate in pumpkin (Cucurbita moschata) seedlings. Environ Pollut. 2017 Jan;220(Pt A):421-430. doi: 10.1016/j.envpol.2016.09.084. Epub 2016 Sep 30. PubMed PMID: 27697378.

18: Corbasson I, Hankinson SE, Stanek EJ 3rd, Reeves KW. Urinary bisphenol-A, phthalate metabolites and body composition in US adults, NHANES 1999-2006. Int J Environ Health Res. 2016 Oct-Dec;26(5-6):606-17. doi: 10.1080/09603123.2016.1233524. Epub 2016 Sep 19. PubMed PMID: 27643383.

19: Hu X, Gu Y, Huang W, Yin D. Phthalate monoesters as markers of phthalate contamination in wild marine organisms. Environ Pollut. 2016 Nov;218:410-418. doi: 10.1016/j.envpol.2016.07.020. Epub 2016 Jul 18. PubMed PMID: 27435611.

20: Wallner P, Kundi M, Hohenblum P, Scharf S, Hutter HP. Phthalate Metabolites, Consumer Habits and Health Effects. Int J Environ Res Public Health. 2016 Jul 15;13(7). pii: E717. doi: 10.3390/ijerph13070717. PubMed PMID: 27428989; PubMed Central PMCID: PMC4962258.