Paeonol
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H591810

CAS#: 552-41-0

Description: Paeonol is a phenolic compound found in peonies such as Paeonia suffruticosa, in Arisaema erubescens, and in Dioscorea japonica. It is a component found in some Traditional Chinese medicine remedies. Paeonol attenuates isoflurane anaesthesia induced hippocampal neurotoxicity via modulation of JNK/ERK/P38MAPK pathway and regulates histone acetylation.

Chemical Structure

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Paeonol
CAS# 552-41-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H591810
Name: Paeonol
CAS#: 552-41-0
Chemical Formula: C9H10O3
Exact Mass: 166.06
Molecular Weight: 166.176
Elemental Analysis: C, 65.05; H, 6.07; O, 28.88

Price and Availability

Size Price Availability Quantity
1g USD 230 2 Weeks
10g USD 380 2 Weeks
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Synonym: Paeonol; NSC 401442; NSC-401442; NSC401442

IUPAC/Chemical Name: 1-(2-Hydroxy-4-methoxyphenyl)ethanone

InChi Key: UILPJVPSNHJFIK-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3

SMILES Code: CC(C1=CC=C(OC)C=C1O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 166.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jin H, Wang M, Wang J, Cao H, Niu W, Du L. Paeonol attenuates isoflurane anaesthesia induced hippocampal neurotoxicity via modulation of JNK/ERK/P38MAPK pathway and regulates histone acetylation in neonatal rat. J Matern Fetal Neonatal Med. 2018 Jun 10:1-211. doi: 10.1080/14767058.2018.1487396. [Epub ahead of print] PubMed PMID: 29886761.

2: Liu X, Xu Q, Mei L, Lei H, Wen Q, Miao J, Huang H, Chen D, Du S, Zhang S, Zhou J, Deng R, Li Y, Li C, Li H. Paeonol attenuates acute lung injury by inhibiting HMGB1 in lipopolysaccharide-induced shock rats. Int Immunopharmacol. 2018 Jun 5;61:169-177. doi: 10.1016/j.intimp.2018.05.032. [Epub ahead of print] PubMed PMID: 29883962.

3: Zhang L, Chen Z, Gong W, Zou Y, Xu F, Chen L, Huang H. Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1. Front Pharmacol. 2018 May 18;9:512. doi: 10.3389/fphar.2018.00512. eCollection 2018. PubMed PMID: 29867511; PubMed Central PMCID: PMC5968333.

4: Saahene RO, Wang J, Wang ML, Agbo E, Pang D. The Antitumor Mechanism of Paeonol on CXCL4/CXCR3-B Signals in Breast Cancer Through Induction of Tumor Cell Apoptosis. Cancer Biother Radiopharm. 2018 May 30. doi: 10.1089/cbr.2018.2450. [Epub ahead of print] PubMed PMID: 29847158.

5: Fu J, Yu L, Luo J, Huo R, Zhu B. Paeonol induces the apoptosis of the SGC 7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NF κB signaling pathway. Int J Mol Med. 2018 May 23. doi: 10.3892/ijmm.2018.3704. [Epub ahead of print] PubMed PMID: 29845222.

6: Tsai CH, Hsu MH, Huang PH, Hsieh CT, Chiu YM, Shieh DC, Lee YJ, Tsay GJ, Wu YY. A paeonol derivative, YPH-PA3 promotes the differentiation of monocyte/macrophage lineage precursor cells into osteoblasts and enhances their autophagy. Eur J Pharmacol. 2018 Aug 5;832:104-113. doi: 10.1016/j.ejphar.2018.05.024. Epub 2018 May 18. PubMed PMID: 29782859.

7: Zhu XL, Chen JJ, Han F, Pan C, Zhuang TT, Cai YF, Lu YP. Novel antidepressant effects of Paeonol alleviate neuronal injury with concomitant alterations in BDNF, Rac1 and RhoA levels in chronic unpredictable mild stress rats. Psychopharmacology (Berl). 2018 May 12. doi: 10.1007/s00213-018-4915-7. [Epub ahead of print] PubMed PMID: 29752492.

8: Sun Z, Du J, Hwang E, Yi TH. Paeonol extracted from Paeonia suffruticosa Andr. ameliorated UVB-induced skin photoaging via DLD/Nrf2/ARE and MAPK/AP-1 pathway. Phytother Res. 2018 May 10. doi: 10.1002/ptr.6100. [Epub ahead of print] PubMed PMID: 29748977.

9: Xu Q, Liu X, Mei L, Wen Q, Chen J, Miao J, Lei H, Huang H, Chen D, Du S, Liu A, Zhang S, Zhou J, Deng R, Li Y, Li C, Li H. Paeonol Reduces the Nucleocytoplasmic Transportation of HMGB1 by Upregulating HDAC3 in LPS-Induced RAW264.7 Cells. Inflammation. 2018 May 7. doi: 10.1007/s10753-018-0800-0. [Epub ahead of print] PubMed PMID: 29736733.

10: Sun X, Wang P, Yao LP, Wang W, Gao YM, Zhang J, Fu YJ. Paeonol alleviated acute alcohol-induced liver injury via SIRT1/Nrf2/NF-κB signaling pathway. Environ Toxicol Pharmacol. 2018 Jun;60:110-117. doi: 10.1016/j.etap.2018.04.016. Epub 2018 Apr 22. PubMed PMID: 29704732.

11: Zhang RH, Li CR, Yang H, Li MN, Tsim KWK, Li P, Gao W. An UPLC-MS/MS method for simultaneous determination of multiple constituents in Guizhi Fuling capsule with ultrafast positive/negative ionization switching. Chin J Nat Med. 2018 Apr;16(4):313-320. doi: 10.1016/S1875-5364(18)30061-X. PubMed PMID: 29703331.

12: Choy KW, Murugan D, Mustafa MR. Natural products targeting ER stress pathway for the treatment of cardiovascular diseases. Pharmacol Res. 2018 Jun;132:119-129. doi: 10.1016/j.phrs.2018.04.013. Epub 2018 Apr 21. Review. PubMed PMID: 29684674.

13: Jiao MJ, Deng Z, Zhang J, Wang SH, Cui WJ, Zhang GY, Liu A. [Preparation and quality standard of standard decoction of Chinese herbal medicine containing volatile components-case study of Moutan Cortex]. Zhongguo Zhong Yao Za Zhi. 2018 Mar;43(5):891-896. doi: 10.19540/j.cnki.cjcmm.20180105.017. Chinese. PubMed PMID: 29676084.

14: Liao M, Cheng X, Zhang X, Diao X, Liang C, Zhang L. Qualitative and Quantitative Analyses of Active Constituents in Trollius ledebourii. J Chromatogr Sci. 2018 Apr 13. doi: 10.1093/chromsci/bmy035. [Epub ahead of print] PubMed PMID: 29668849.

15: Zhu N, Wu XX, Tian Y, Zhu JX, Li JC. Pharmacokinetic and Pharmacodynamics of Self-Assembled Cubic Liquid Crystalline Nanoparticle Gel After Transdermal Administration. Med Sci Monit. 2018 Apr 18;24:2330-2338. PubMed PMID: 29666359; PubMed Central PMCID: PMC5926275.

16: Zhang WW, Xu F, Wang D, Ye J, Cai SQ. Buyang Huanwu Decoction ameliorates ischemic stroke by modulating multiple targets with multiple components: In vitro evidences. Chin J Nat Med. 2018 Mar;16(3):194-202. doi: 10.1016/S1875-5364(18)30047-5. PubMed PMID: 29576055.

17: Zhao B, Shi QJ, Zhang ZZ, Wang SY, Wang X, Wang H. Protective effects of paeonol on subacute/chronic brain injury during cerebral ischemia in rats. Exp Ther Med. 2018 Apr;15(4):3836-3846. doi: 10.3892/etm.2018.5893. Epub 2018 Feb 26. PubMed PMID: 29563983; PubMed Central PMCID: PMC5858057.

18: Yang CT, Lu GL, Hsu SF, MacDonald I, Chiou LC, Hung SY, Chen YH. Paeonol promotes hippocampal synaptic transmission: The role of the Kv2.1 potassium channel. Eur J Pharmacol. 2018 May 15;827:227-237. doi: 10.1016/j.ejphar.2018.03.020. Epub 2018 Mar 15. PubMed PMID: 29550337.

19: Wu J, Sun C, Wang R, Li J, Zhou M, Yan M, Xue X, Wang C. Cardioprotective effect of paeonol against epirubicin-induced heart injury via regulating miR-1 and PI3K/AKT pathway. Chem Biol Interact. 2018 Apr 25;286:17-25. doi: 10.1016/j.cbi.2018.02.035. Epub 2018 Mar 2. PubMed PMID: 29505745.

20: Li C, Yang L, Wu H, Dai M. Paeonol Inhibits Oxidized Low-Density Lipoprotein-Induced Vascular Endothelial Cells Autophagy by Upregulating the Expression of miRNA-30a. Front Pharmacol. 2018 Feb 8;9:95. doi: 10.3389/fphar.2018.00095. eCollection 2018. PubMed PMID: 29472864; PubMed Central PMCID: PMC5809422.