WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597232
CAS#: 997-68-2
Description: L-Saccharopine is a product of breakdown of essential amino acid Lysine. Saccharopine is also part of the α-aminoadipate pathway of fungal lysine biosynthesis.
Hodoodo Cat#: H597232
Name: L-Saccharopine
CAS#: 997-68-2
Chemical Formula: C11H20N2O6
Exact Mass: 276.13
Molecular Weight: 276.280
Elemental Analysis: C, 47.82; H, 7.30; N, 10.14; O, 34.74
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: L-Saccharopine; accharopin; Saccharopine;
IUPAC/Chemical Name: ((S)-5-amino-5-carboxypentyl)-L-glutamic acid
InChi Key: ZDGJAHTZVHVLOT-YUMQZZPRSA-N
InChi Code: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/t7-,8-/m0/s1
SMILES Code: O=C(O)CC[C@@H](C(O)=O)NCCCC[C@H](N)C(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 276.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Sato T, Ito Y, Nagasawa T. Regulatory effects of the L-lysine metabolites, L-2-aminoadipic acid and L-pipecolic acid, on protein turnover in C2C12 myotubes. Biosci Biotechnol Biochem. 2016 Jul 18:1-8. [Epub ahead of print] PubMed PMID: 27427787.
2: Pena IA, Marques LA, Laranjeira AB, Yunes JA, Eberlin MN, Arruda P. Simultaneous detection of lysine metabolites by a single LC-MS/MS method: monitoring lysine degradation in mouse plasma. Springerplus. 2016 Feb 25;5:172. doi: 10.1186/s40064-016-1809-1. eCollection 2016. PubMed PMID: 27026869; PubMed Central PMCID: PMC4766172.
3: Kumar VP, Thomas LM, Bobyk KD, Andi B, Cook PF, West AH. Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2012 Jan 31;51(4):857-66. doi: 10.1021/bi201808. Epub 2012 Jan 23. PubMed PMID: 22243403; PubMed Central PMCID: PMC3297426.
4: Yoshida N, Akazawa S, Katsuragi T, Tani Y. Characterization of two fructosyl-amino acid oxidase homologs of Schizosaccharomyces pombe. J Biosci Bioeng. 2004;97(4):278-80. PubMed PMID: 16233628.
5: Storts DR, Bhattacharjee JK. Purification and properties of saccharopine dehydrogenase (glutamate forming) in the Saccharomyces cerevisiae lysine biosynthetic pathway. J Bacteriol. 1987 Jan;169(1):416-8. PubMed PMID: 3098733; PubMed Central PMCID: PMC211784.
6: Hermann P, Meinel K. [A simple method for extraction of L-saccharopine from Neurospora crassa]. Pharmazie. 1976;31(2):132. German. PubMed PMID: 134378.
